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For five different brands of acetylsalicylic acid (ASA) preparations the in vitro/in vivo data were determined and tested for comparability. The in vitro dissolution rates were determined by two different methods (Paddle, rotating basket) whereas the in vivo data were obtained from 15 volunteers in a 5-fold cross-over trial. The markedly worse in vitro dissolution (rotating basket) of one preparation is in contrast to the in vivo data which showed bioequivalency of all five preparations. It is doubled that in vitro measurements alone reveal sufficient informations for any predictions of the in vivo characteristics (e.g. bioavailability) of a preparation. It was possible to determine separately ASA and salicylic acid using a highly selective HPLC-method developed by us.
M Nieder, and
J Rasper, and
W Gielsdorf, and
D Russmann, and
H Jaeger
January 1988,
Arzneimittel-Forschung,
M Nieder, and
J Rasper, and
W Gielsdorf, and
D Russmann, and
H Jaeger
January 1975,
Acta pharmaceutica Suecica,
M Nieder, and
J Rasper, and
W Gielsdorf, and
D Russmann, and
H Jaeger
January 1985,
Arzneimittel-Forschung,
M Nieder, and
J Rasper, and
W Gielsdorf, and
D Russmann, and
H Jaeger
January 1975,
Acta pharmaceutica Suecica,
M Nieder, and
J Rasper, and
W Gielsdorf, and
D Russmann, and
H Jaeger
July 1985,
Acta pharmaceutica Hungarica,
M Nieder, and
J Rasper, and
W Gielsdorf, and
D Russmann, and
H Jaeger
November 1990,
Acta pharmaceutica Hungarica,
M Nieder, and
J Rasper, and
W Gielsdorf, and
D Russmann, and
H Jaeger
January 1983,
Arzneimittel-Forschung,
M Nieder, and
J Rasper, and
W Gielsdorf, and
D Russmann, and
H Jaeger
September 1985,
Acta pharmaceutica Hungarica,
M Nieder, and
J Rasper, and
W Gielsdorf, and
D Russmann, and
H Jaeger
May 1953,
Medizinische Klinik,
M Nieder, and
J Rasper, and
W Gielsdorf, and
D Russmann, and
H Jaeger
September 1978,
Acta pharmaceutica Hungarica,
