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To study the mechanisms of inhibitory action of antiepileptic drugs on foetal head growth, determinations were made of the growth hormone, thyrotropin and thyroid hormone levels in the sera of pregnant women, and the correlations between each hormone concentration and the foetal head circumference were studied. The thyroxine level decreased in the maternal serum and in the cord blood, and the thyrotropin level also became lower in the epileptic mother taking antiepileptic drugs. The growth hormone level in the umbilical vein sample of the epileptic mother was lower than that in the controls. The correlations between the head circumference of an infant at delivery and the decreased levels of the hormones seemed to indicate that a decrease in the thyroxine level, caused by antiepileptic drugs, produced the foetal head growth retardation.
S Kaneko, and
T Hirano, and
Y Fukushima, and
T Sato, and
Y Nomura, and
S Shinagawa, and
Y Ogawa
July 1982,
No to shinkei = Brain and nerve,
S Kaneko, and
T Hirano, and
Y Fukushima, and
T Sato, and
Y Nomura, and
S Shinagawa, and
Y Ogawa
August 1977,
The Journal of clinical endocrinology and metabolism,
S Kaneko, and
T Hirano, and
Y Fukushima, and
T Sato, and
Y Nomura, and
S Shinagawa, and
Y Ogawa
July 1981,
Lancet (London, England),
S Kaneko, and
T Hirano, and
Y Fukushima, and
T Sato, and
Y Nomura, and
S Shinagawa, and
Y Ogawa
March 1980,
Acta endocrinologica,
S Kaneko, and
T Hirano, and
Y Fukushima, and
T Sato, and
Y Nomura, and
S Shinagawa, and
Y Ogawa
January 1980,
Minerva pediatrica,
S Kaneko, and
T Hirano, and
Y Fukushima, and
T Sato, and
Y Nomura, and
S Shinagawa, and
Y Ogawa
September 1985,
Human nutrition. Clinical nutrition,
S Kaneko, and
T Hirano, and
Y Fukushima, and
T Sato, and
Y Nomura, and
S Shinagawa, and
Y Ogawa
January 1980,
Endocrinologie,
S Kaneko, and
T Hirano, and
Y Fukushima, and
T Sato, and
Y Nomura, and
S Shinagawa, and
Y Ogawa
January 1980,
Endocrinologie,
S Kaneko, and
T Hirano, and
Y Fukushima, and
T Sato, and
Y Nomura, and
S Shinagawa, and
Y Ogawa
October 2001,
Clinical chemistry and laboratory medicine,
S Kaneko, and
T Hirano, and
Y Fukushima, and
T Sato, and
Y Nomura, and
S Shinagawa, and
Y Ogawa
January 1987,
Reproduction, nutrition, developpement,
