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The antitussive and respiratory stimulant properties of N-(2'-ethylpyrrolidino)diphenylacetamide hydrochloride (F 1459) in animals are reported. In the mechanical stimulation of the trachea in guinea pigs and after intraperitoneal administration of the product, F 1459 showed a better antitussive action as compared to oxeladin, zipeprol, codeine and clobutinol. Low intraduodenal doses of F 1459 also reduced in cats the cough induced by the electrical stimulation of the superior laryngeal nerve. In anesthetized dogs whose respiratory functions had been depressed by morphine, F 1459 significantly increased the volume inspired per minute, an effect not due to any uncoupling effect on oxidative phosphorylation. F 1459 has local anesthetic and broncholytic properties that may play a role in the mechanism of its antitussive action. Contrarily to codeine, the test compound did not induce a decrease in the intestinal transit.
J P Tarayre, and
P Vilain, and
H Lauressergues, and
J Cauquil, and
M Bru, and
V Caillol, and
G Pouget, and
A M Jougla, and
M Go
June 1966,
Archives internationales de pharmacodynamie et de therapie,
J P Tarayre, and
P Vilain, and
H Lauressergues, and
J Cauquil, and
M Bru, and
V Caillol, and
G Pouget, and
A M Jougla, and
M Go
January 1989,
Polish journal of pharmacology and pharmacy,
J P Tarayre, and
P Vilain, and
H Lauressergues, and
J Cauquil, and
M Bru, and
V Caillol, and
G Pouget, and
A M Jougla, and
M Go
January 1965,
Acta physiologica Academiae Scientiarum Hungaricae,
J P Tarayre, and
P Vilain, and
H Lauressergues, and
J Cauquil, and
M Bru, and
V Caillol, and
G Pouget, and
A M Jougla, and
M Go
December 1966,
Japanese journal of pharmacology,
J P Tarayre, and
P Vilain, and
H Lauressergues, and
J Cauquil, and
M Bru, and
V Caillol, and
G Pouget, and
A M Jougla, and
M Go
March 1959,
Archives internationales de pharmacodynamie et de therapie,
J P Tarayre, and
P Vilain, and
H Lauressergues, and
J Cauquil, and
M Bru, and
V Caillol, and
G Pouget, and
A M Jougla, and
M Go
January 1969,
Archives internationales de pharmacodynamie et de therapie,
J P Tarayre, and
P Vilain, and
H Lauressergues, and
J Cauquil, and
M Bru, and
V Caillol, and
G Pouget, and
A M Jougla, and
M Go
May 1955,
Archives internationales de pharmacodynamie et de therapie,
J P Tarayre, and
P Vilain, and
H Lauressergues, and
J Cauquil, and
M Bru, and
V Caillol, and
G Pouget, and
A M Jougla, and
M Go
January 1971,
Il Farmaco; edizione scientifica,
J P Tarayre, and
P Vilain, and
H Lauressergues, and
J Cauquil, and
M Bru, and
V Caillol, and
G Pouget, and
A M Jougla, and
M Go
September 1959,
Bollettino della Societa italiana di biologia sperimentale,
J P Tarayre, and
P Vilain, and
H Lauressergues, and
J Cauquil, and
M Bru, and
V Caillol, and
G Pouget, and
A M Jougla, and
M Go
August 1951,
The American journal of digestive diseases,
