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To study the influence of various in vitro release rates and of coadministration with food on bioavailability of isosorbide dinitrate (ISDN; isoket retard 40) and its mononitrate metabolites from sustained-release formulations the pharmacokinetics of two experimental batches of tablets with different release rates containing 40 mg 14C-ISDN each were studied in six human volunteers. One of the formulations was not only administered after fasting but aslo with a standard meal. In all cases approx. 80% of the administered radioactivity were recovered in the urine and 5% in the faeces during 3 days demonstrating extensive absorption. Any influence of release rates or food on absorption rates could not be detected. When administered after fasting either formulation was bioequivalent. Coadministration of a meal enhanced ISDN plasma levels in some subjects although no statistically significant difference in extent of bioavailability was observed. Availability of the mononitrates was unaffected by food.
L F Chasseaud, and
T Taylor, and
R M Major, and
I W Taylor, and
V Luckow, and
A Darragh, and
R F Lambe
September 1988,
Arzneimittel-Forschung,
L F Chasseaud, and
T Taylor, and
R M Major, and
I W Taylor, and
V Luckow, and
A Darragh, and
R F Lambe
June 1982,
Journal of pharmaceutical sciences,
L F Chasseaud, and
T Taylor, and
R M Major, and
I W Taylor, and
V Luckow, and
A Darragh, and
R F Lambe
January 1990,
Clinical therapeutics,
L F Chasseaud, and
T Taylor, and
R M Major, and
I W Taylor, and
V Luckow, and
A Darragh, and
R F Lambe
August 1983,
International journal of clinical pharmacology, therapy, and toxicology,
L F Chasseaud, and
T Taylor, and
R M Major, and
I W Taylor, and
V Luckow, and
A Darragh, and
R F Lambe
January 1981,
Arzneimittel-Forschung,
L F Chasseaud, and
T Taylor, and
R M Major, and
I W Taylor, and
V Luckow, and
A Darragh, and
R F Lambe
January 1991,
Indian heart journal,
L F Chasseaud, and
T Taylor, and
R M Major, and
I W Taylor, and
V Luckow, and
A Darragh, and
R F Lambe
January 1980,
Chest,
L F Chasseaud, and
T Taylor, and
R M Major, and
I W Taylor, and
V Luckow, and
A Darragh, and
R F Lambe
October 1997,
Biological & pharmaceutical bulletin,
L F Chasseaud, and
T Taylor, and
R M Major, and
I W Taylor, and
V Luckow, and
A Darragh, and
R F Lambe
January 1981,
Arzneimittel-Forschung,
L F Chasseaud, and
T Taylor, and
R M Major, and
I W Taylor, and
V Luckow, and
A Darragh, and
R F Lambe
January 1985,
European journal of clinical pharmacology,
