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A 20-second bolus of serotonin (5-hydroxytryptamine, 5HT), prostaglandin E1 (PGE1) or norepinephrine (NE) was infused into the pulmonary arteries of lungs isolated from 26-day gestation fetal, newborn (within 12 h of birth), and young adult rabbits. In each case the concentration of the infused substrate was much less than the apparent Michaelis constant for the uptake process. At these low concentrations there was no observable vasoactivity. In order to assure a constant ratio of flow to capillary surface area (independent of lung size), perfusate flow was adjusted so that the retention time of a vascular dye was approximately 7 s. Under these conditions the isolated adult rabbit lungs inactivate a similar fraction (40-50%) of each of the substrates. In contrast, isolated newborn rabbit lungs inactivate about 20% of the infused PGE1, 90% of the 5HT, and 60% of the NE, and the nonventilated, previable fetal rabbit lungs inactivate about 20% of the infused PGE1, 60% of the 5HT, and 80% of the NE.
E B Olson, and
J Rankin
January 1983,
General pharmacology,
E B Olson, and
J Rankin
November 1972,
British journal of pharmacology,
E B Olson, and
J Rankin
June 1987,
The American review of respiratory disease,
E B Olson, and
J Rankin
September 1983,
Environmental health perspectives,
E B Olson, and
J Rankin
January 1982,
Fiziologicheskii zhurnal,
E B Olson, and
J Rankin
January 1983,
Biology of the neonate,
E B Olson, and
J Rankin
January 1978,
Blood vessels,
E B Olson, and
J Rankin
August 1983,
Prostaglandins,
E B Olson, and
J Rankin
January 1978,
Respiration; international review of thoracic diseases,
E B Olson, and
J Rankin
May 1999,
Biulleten' eksperimental'noi biologii i meditsiny,
