BIOMAT Database Logo BIOMAT Database Logo

[Effect of 5-bromodeoxyuridine concentration on sister chromatid exchange frequency in consecutive replication cycles]. 1983

A A Zhloba, and N V Luchnik

A yield of single and twin sister chromatid exchanges (SCE) in Chinese hamster cells incubated at different concentrations of 5'-bromodeoxyuridine (BrdUrd) has been studied. The ratio of SCEs formed in the second and in the first cycle has been discovered to be dependent on the dose of BrdUrd; it is 1.5:1 for the high concentration of BrdUrd and 1:1 for the lowest one. The authors arrived at a conclusion that the observed level of SCEs--0.1 per chromosome per cycle for the lowest concentration is spontaneous.

UI MeSH Term Description Entries
D001973 Bromodeoxyuridine A nucleoside that substitutes for thymidine in DNA and thus acts as an antimetabolite. It causes breaks in chromosomes and has been proposed as an antiviral and antineoplastic agent. It has been given orphan drug status for use in the treatment of primary brain tumors. BUdR,BrdU,Bromouracil Deoxyriboside,Broxuridine,5-Bromo-2'-deoxyuridine,5-Bromodeoxyuridine,NSC-38297,5 Bromo 2' deoxyuridine,5 Bromodeoxyuridine,Deoxyriboside, Bromouracil
D002453 Cell Cycle The complex series of phenomena, occurring between the end of one CELL DIVISION and the end of the next, by which cellular material is duplicated and then divided between two daughter cells. The cell cycle includes INTERPHASE, which includes G0 PHASE; G1 PHASE; S PHASE; and G2 PHASE, and CELL DIVISION PHASE. Cell Division Cycle,Cell Cycles,Cell Division Cycles,Cycle, Cell,Cycle, Cell Division,Cycles, Cell,Cycles, Cell Division,Division Cycle, Cell,Division Cycles, Cell
D002478 Cells, Cultured Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others. Cultured Cells,Cell, Cultured,Cultured Cell
D003412 Cricetulus A genus of the family Muridae consisting of eleven species. C. migratorius, the grey or Armenian hamster, and C. griseus, the Chinese hamster, are the two species used in biomedical research. Hamsters, Armenian,Hamsters, Chinese,Hamsters, Grey,Armenian Hamster,Armenian Hamsters,Chinese Hamster,Chinese Hamsters,Grey Hamster,Grey Hamsters,Hamster, Armenian,Hamster, Chinese,Hamster, Grey
D003434 Crossing Over, Genetic The reciprocal exchange of segments at corresponding positions along pairs of homologous CHROMOSOMES by symmetrical breakage and crosswise rejoining forming cross-over sites (HOLLIDAY JUNCTIONS) that are resolved during CHROMOSOME SEGREGATION. Crossing-over typically occurs during MEIOSIS but it may also occur in the absence of meiosis, for example, with bacterial chromosomes, organelle chromosomes, or somatic cell nuclear chromosomes. Crossing Over,Crossing-Over, Genetic,Crossing Overs,Genetic Crossing Over,Genetic Crossing-Over
D004305 Dose-Response Relationship, Drug The relationship between the dose of an administered drug and the response of the organism to the drug. Dose Response Relationship, Drug,Dose-Response Relationships, Drug,Drug Dose-Response Relationship,Drug Dose-Response Relationships,Relationship, Drug Dose-Response,Relationships, Drug Dose-Response
D006224 Cricetinae A subfamily in the family MURIDAE, comprising the hamsters. Four of the more common genera are Cricetus, CRICETULUS; MESOCRICETUS; and PHODOPUS. Cricetus,Hamsters,Hamster
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D012854 Sister Chromatid Exchange An exchange of segments between the sister chromatids of a chromosome, either between the sister chromatids of a meiotic tetrad or between the sister chromatids of a duplicated somatic chromosome. Its frequency is increased by ultraviolet and ionizing radiation and other mutagenic agents and is particularly high in BLOOM SYNDROME. Chromatid Exchange, Sister,Chromatid Exchanges, Sister,Exchange, Sister Chromatid,Exchanges, Sister Chromatid,Sister Chromatid Exchanges

Related Publications

A A Zhloba, and N V Luchnik
Effect of 5-bromodeoxyuridine substitution on sister chromatid exchange induction by chemicals.
January 1984, Chromosoma,
A A Zhloba, and N V Luchnik
5-bromodeoxyuridine induced sister chromatid exchange frequencies in primate lymphocytes.
May 1982, Experientia,
A A Zhloba, and N V Luchnik
The effect of cell proliferation, bromodeoxyuridine concentration, and deoxynucleoside triphosphate pools on sister chromatid exchange induction.
January 1984, Basic life sciences,
A A Zhloba, and N V Luchnik
Effect of mitomycin C, hydroxylamine & bromodeoxyuridine on cell cycle kinetics & sister chromatid exchange frequency of muntjac lymphocytes.
October 1982, Indian journal of experimental biology,
A A Zhloba, and N V Luchnik
Effect of bromodeoxyuridine on induced sister chromatid exchanges.
January 1984, Basic life sciences,
A A Zhloba, and N V Luchnik
Bromodeoxyuridine differential chromatid staining technique: a new approach to examining sister chromatid exchange and cell replication kinetics.
January 1978, Methods in cell biology,
A A Zhloba, and N V Luchnik
[Effect of sodium diphenylhydantoin on sister chromatid exchange frequency in mice].
January 1990, Archivos de investigacion medica,
A A Zhloba, and N V Luchnik
The effect of simultaneous exposure to bromodeoxyuridine and methyl methanesulphonate on sister-chromatid exchange frequency in cultured human lymphocytes.
October 1993, Mutation research,
A A Zhloba, and N V Luchnik
The Effect of Bromodeoxyuridine on Spontaneous Sister Chromatid Exchange Frequency in Rabbit (Oryctolagus cuniculus) and Coypu (Myocastor coypu) Chromosomes.
January 2016, Folia biologica,
A A Zhloba, and N V Luchnik
Effect of exogenous thymidine on sister-chromatid exchange frequency in Chinese hamster ovary cells with bromodeoxyuridine- and chlorodeoxyuridine-substituted chromosomes.
December 1987, Mutation research,
Copied contents to your clipboard!