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The potential of eugenol and of clove leaf oil, which contains a high concentration of eugenol, to induce delayed skin hypersensitivity or to elicit reactions due to pre-existing skin sensitization in man was evaluated by analysing patch-test data. Results from a total of 11,632 patch tests on eugenol itself, on various consumer products containing eugenol and/or clove leaf oil, and on fragrance blends containing eugenol and/or clove leaf oil were collected from fragrance and formulation companies. One instance of induced hypersensitivity and one instance of pre-existing sensitization were observed at eugenol patch-test concentrations of 5 X 10(-2) and 9 X 10(-2)% respectively. In both cases, subsequent patch testing showed skin responses to mixtures of eugenol and isoeugenol, but no further attempt was made to define the causative agent. The survey indicates that, at the concentrations present in consumer products, eugenol alone or as part of clove leaf oil has a very low potential either to elicit pre-existing sensitization ('elicited' reactions) or to induce hypersensitivity ('induced' reactions).
A S Rothenstein, and
K A Booman, and
J Dorsky, and
K A Kohrman, and
E A Schwoeppe, and
R I Sedlak, and
R J Steltenkamp, and
G R Thompson
January 2008,
Journal of dietary supplements,
A S Rothenstein, and
K A Booman, and
J Dorsky, and
K A Kohrman, and
E A Schwoeppe, and
R I Sedlak, and
R J Steltenkamp, and
G R Thompson
May 2017,
Drug discoveries & therapeutics,
A S Rothenstein, and
K A Booman, and
J Dorsky, and
K A Kohrman, and
E A Schwoeppe, and
R I Sedlak, and
R J Steltenkamp, and
G R Thompson
January 2001,
Contact dermatitis,
A S Rothenstein, and
K A Booman, and
J Dorsky, and
K A Kohrman, and
E A Schwoeppe, and
R I Sedlak, and
R J Steltenkamp, and
G R Thompson
August 2006,
Journal of agricultural and food chemistry,
A S Rothenstein, and
K A Booman, and
J Dorsky, and
K A Kohrman, and
E A Schwoeppe, and
R I Sedlak, and
R J Steltenkamp, and
G R Thompson
January 1980,
Stomatoloski glasnik Srbije,
A S Rothenstein, and
K A Booman, and
J Dorsky, and
K A Kohrman, and
E A Schwoeppe, and
R I Sedlak, and
R J Steltenkamp, and
G R Thompson
January 1988,
Contact dermatitis,
A S Rothenstein, and
K A Booman, and
J Dorsky, and
K A Kohrman, and
E A Schwoeppe, and
R I Sedlak, and
R J Steltenkamp, and
G R Thompson
March 2023,
Molecules (Basel, Switzerland),
A S Rothenstein, and
K A Booman, and
J Dorsky, and
K A Kohrman, and
E A Schwoeppe, and
R I Sedlak, and
R J Steltenkamp, and
G R Thompson
January 2017,
Food chemistry,
A S Rothenstein, and
K A Booman, and
J Dorsky, and
K A Kohrman, and
E A Schwoeppe, and
R I Sedlak, and
R J Steltenkamp, and
G R Thompson
December 2017,
Microbial pathogenesis,
A S Rothenstein, and
K A Booman, and
J Dorsky, and
K A Kohrman, and
E A Schwoeppe, and
R I Sedlak, and
R J Steltenkamp, and
G R Thompson
January 2012,
Journal of oleo science,
