K O Goh, and
R Qazi, and
M Owens, and
M Herrmann, and
J M Bennett
UI
MeSH Term
Description
Entries
D007938
Leukemia
A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)
Genes whose gain-of-function alterations lead to NEOPLASTIC CELL TRANSFORMATION. They include, for example, genes for activators or stimulators of CELL PROLIFERATION such as growth factors, growth factor receptors, protein kinases, signal transducers, nuclear phosphoproteins, and transcription factors. A prefix of "v-" before oncogene symbols indicates oncogenes captured and transmitted by RETROVIRUSES; the prefix "c-" before the gene symbol of an oncogene indicates it is the cellular homolog (PROTO-ONCOGENES) of a v-oncogene.
Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000208
Acute Disease
Disease having a short and relatively severe course.
Acute Diseases,Disease, Acute,Diseases, Acute
D000328
Adult
A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available.
Adults
Related Publications
K O Goh, and
R Qazi, and
M Owens, and
M Herrmann, and
J M Bennett