-transparent.png){kind=logo}
Changes in values for myoglobin, total creatine kinase (EC 2.7.3.2), and creatine kinase B-subunit in the serum of patients with thyroid disease are compared with values for these during the 24-h after myocardial infarction. Concentrations of all three of these muscle-derived proteins were significantly higher than normal in patients with primary hypothyroidism, and declined with treatment. Values for total creatine kinase activity were below-normal in hyperthyroid patients, but increased after treatment. Values for total creatine kinase and, to a lesser extent, myoglobin in hypothyroidism extend into the range of values observed after myocardial infarction. The mechanism of the changes in these analytes in hypothyroidism may be related to increased leakage from skeletal-muscle cells or diminished clearance from the circulation, or both.
I Docherty, and
J S Harrop, and
K R Hine, and
M R Hopton, and
H L Matthews, and
C J Taylor
December 1984,
Scandinavian journal of clinical and laboratory investigation,
I Docherty, and
J S Harrop, and
K R Hine, and
M R Hopton, and
H L Matthews, and
C J Taylor
December 1979,
Clinical biochemistry,
I Docherty, and
J S Harrop, and
K R Hine, and
M R Hopton, and
H L Matthews, and
C J Taylor
July 1979,
Clinical chemistry,
I Docherty, and
J S Harrop, and
K R Hine, and
M R Hopton, and
H L Matthews, and
C J Taylor
February 1982,
Clinical chemistry,
I Docherty, and
J S Harrop, and
K R Hine, and
M R Hopton, and
H L Matthews, and
C J Taylor
February 1987,
Annals of the rheumatic diseases,
I Docherty, and
J S Harrop, and
K R Hine, and
M R Hopton, and
H L Matthews, and
C J Taylor
April 1982,
Clinical chemistry,
I Docherty, and
J S Harrop, and
K R Hine, and
M R Hopton, and
H L Matthews, and
C J Taylor
May 1980,
British heart journal,
I Docherty, and
J S Harrop, and
K R Hine, and
M R Hopton, and
H L Matthews, and
C J Taylor
January 1985,
Acta neurologica Scandinavica,
I Docherty, and
J S Harrop, and
K R Hine, and
M R Hopton, and
H L Matthews, and
C J Taylor
November 1971,
Clinica chimica acta; international journal of clinical chemistry,
I Docherty, and
J S Harrop, and
K R Hine, and
M R Hopton, and
H L Matthews, and
C J Taylor
January 1985,
Journal of neurology,
