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The effect of aqueous extracts of cotton bract (CBE) on platelet secretion and aggregation was examined by using washed bovine and human platelets. The CBE promoted the release of 75% to 90% of the 5-hydroxytryptamine (5-HT) stored in both human and bovine platelets in a dose-dependent manner. This release reaction occurred without the lysis of the platelets and was not inhibited by indomethacin, 2-deoxyglucose, or KCN. Fractionation of the CBE indicated that the platelet secretagogue present in the CBE was the condensed polyphenol, tannin. In addition to promoting the secretion of 5-HT, tannin also aggregated the platelets in a dose-dependent manner. We conclude that the secretion of platelet 5-HT and the aggregation of platelets by tannin could potentially contribute to the pulmonary symptoms associated with byssinosis.
M S Rohrbach, and
R A Rolstad, and
P B Tracy, and
J A Russell
April 1986,
Environmental health perspectives,
M S Rohrbach, and
R A Rolstad, and
P B Tracy, and
J A Russell
February 1983,
Federation proceedings,
M S Rohrbach, and
R A Rolstad, and
P B Tracy, and
J A Russell
January 1980,
Progress in neuro-psychopharmacology,
M S Rohrbach, and
R A Rolstad, and
P B Tracy, and
J A Russell
April 1971,
Journal of clinical pathology,
M S Rohrbach, and
R A Rolstad, and
P B Tracy, and
J A Russell
July 1974,
The Journal of physiology,
M S Rohrbach, and
R A Rolstad, and
P B Tracy, and
J A Russell
April 1968,
Nature,
M S Rohrbach, and
R A Rolstad, and
P B Tracy, and
J A Russell
October 1970,
Thrombosis et diathesis haemorrhagica,
M S Rohrbach, and
R A Rolstad, and
P B Tracy, and
J A Russell
February 1973,
Nature: New biology,
M S Rohrbach, and
R A Rolstad, and
P B Tracy, and
J A Russell
January 1990,
Current medical research and opinion,
M S Rohrbach, and
R A Rolstad, and
P B Tracy, and
J A Russell
December 1986,
The American review of respiratory disease,
