-transparent.png){kind=logo}
Isomeric 5(6)-(4-pyridyl)- and 6(5)-(4-substituted-phenyl)-2,3-dihydroimidazo[2,1-b]thiazoles were prepared by a mixed benzoin-imidazothione route, and their structures were assigned by spectral comparison to compounds of established substitution pattern. The structural assignment was confirmed by X-ray analysis. Examination of the compounds for antiinflammatory activity by an adjuvant arthritic rat assay revealed strikingly higher potencies for one analogous series than for their isomers. This selectivity was paralleled in the ability to stimulate cell-mediated immunity, as reflected in an oxazolone-induced contact sensitivity model. A drug-receptor complex is proposed that requires at least three sites of interactions.
I Lantos, and
P E Bender, and
K A Razgaitis, and
B M Sutton, and
M J DiMartino, and
D E Griswold, and
D T Walz
September 1985,
Journal of medicinal chemistry,
I Lantos, and
P E Bender, and
K A Razgaitis, and
B M Sutton, and
M J DiMartino, and
D E Griswold, and
D T Walz
October 1971,
Journal of medicinal chemistry,
I Lantos, and
P E Bender, and
K A Razgaitis, and
B M Sutton, and
M J DiMartino, and
D E Griswold, and
D T Walz
January 1990,
Drug metabolism and disposition: the biological fate of chemicals,
I Lantos, and
P E Bender, and
K A Razgaitis, and
B M Sutton, and
M J DiMartino, and
D E Griswold, and
D T Walz
July 1980,
Il Farmaco; edizione scientifica,
I Lantos, and
P E Bender, and
K A Razgaitis, and
B M Sutton, and
M J DiMartino, and
D E Griswold, and
D T Walz
November 2016,
Bioorganic & medicinal chemistry,
I Lantos, and
P E Bender, and
K A Razgaitis, and
B M Sutton, and
M J DiMartino, and
D E Griswold, and
D T Walz
May 1988,
Il Farmaco; edizione scientifica,
I Lantos, and
P E Bender, and
K A Razgaitis, and
B M Sutton, and
M J DiMartino, and
D E Griswold, and
D T Walz
June 2010,
Archiv der Pharmazie,
I Lantos, and
P E Bender, and
K A Razgaitis, and
B M Sutton, and
M J DiMartino, and
D E Griswold, and
D T Walz
February 2011,
Tetrahedron letters,
I Lantos, and
P E Bender, and
K A Razgaitis, and
B M Sutton, and
M J DiMartino, and
D E Griswold, and
D T Walz
October 2023,
Future medicinal chemistry,
I Lantos, and
P E Bender, and
K A Razgaitis, and
B M Sutton, and
M J DiMartino, and
D E Griswold, and
D T Walz
November 1980,
Bollettino chimico farmaceutico,
