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Radiologic and biochemical abnormalities associated with nutritional hypophosphatemic rickets were discovered in a 945-g preterm infant despite daily supplementation with 800 to 1,600 IU of ergocalciferol (vitamin D2) and an elevated serum 25-hydroxyvitamin D concentration. Vitamin D supplementation was stopped, and the rickets was corrected by phosphorus supplement alone with the use of a unique technique of long-term, continuous nasogastric phosphorus infusion. Normophosphatemia was rapidly achieved and effectively maintained. Hypocalcemia did not occur at rates of infusion of 100 mg of elemental phosphorus per day. The data are consistent with specific phosphorus deficiency as the cause of rickets in this infant, rather than insufficient vitamin D intake or disturbed vitamin D metabolism. We speculated that continuous phosphorus infusion prevents the intermittent hyperphosphatemia of bolus phosphorus supplement and that continuous phosphorus infusion may be useful in the treatment of other hypophosphatemic states of infancy.
W W Koo, and
G Antony, and
L H Stevens
November 1991,
Pediatric nephrology (Berlin, Germany),
W W Koo, and
G Antony, and
L H Stevens
October 1987,
Drug intelligence & clinical pharmacy,
W W Koo, and
G Antony, and
L H Stevens
February 1985,
The Journal of pediatrics,
W W Koo, and
G Antony, and
L H Stevens
April 2015,
Current osteoporosis reports,
W W Koo, and
G Antony, and
L H Stevens
July 1996,
The Journal of pediatrics,
W W Koo, and
G Antony, and
L H Stevens
March 2012,
Indian journal of endocrinology and metabolism,
W W Koo, and
G Antony, and
L H Stevens
April 2001,
Reviews in endocrine & metabolic disorders,
W W Koo, and
G Antony, and
L H Stevens
January 2003,
Endocrine development,
W W Koo, and
G Antony, and
L H Stevens
February 2019,
Pediatric clinics of North America,
