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Ventriculocisternal perfusion (VCP) of artificial cerebrospinal fluid (CSF) was performed in pentobarbital-anesthetized dogs. Renal function was studied in protocols consisting of a 1-h experimental period in which the animals received either CSF with an elevated sodium concentration (300 mM, high Na) via VCP or antidiuretic hormone (ADH) intravenously, bracketed by 1-h control and recovery periods. High Na VCP caused an increase in plasma ADH measured by radioimmunoassay (to 176% of control) that coincided with a natriuresis (to 180% of control). In a second set of experiments, these changes in endogenous ADH were mimicked experimentally with intravenous infusions of synthetic ADH in animals receiving continuous VCP with normal sodium artificial CSF. The dose-response relationship between log ADH and urinary sodium excretion for the intravenous ADH experiments was not different from the relationship for those experiments in which ADH was elevated as a consequence of high Na VCP. These results suggest that ADH causes part, if not all, the natriuresis induced by high Na VCP.
E T Pierce, and
R J Grekin, and
D R Mouw
August 1979,
The American journal of physiology,
E T Pierce, and
R J Grekin, and
D R Mouw
April 1985,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
E T Pierce, and
R J Grekin, and
D R Mouw
January 1989,
Acta physiologica Scandinavica. Supplementum,
E T Pierce, and
R J Grekin, and
D R Mouw
December 1983,
The American journal of physiology,
E T Pierce, and
R J Grekin, and
D R Mouw
January 1984,
The American journal of physiology,
E T Pierce, and
R J Grekin, and
D R Mouw
April 1983,
The American journal of physiology,
E T Pierce, and
R J Grekin, and
D R Mouw
June 1991,
The American journal of physiology,
E T Pierce, and
R J Grekin, and
D R Mouw
January 1985,
Proceedings of the European Dialysis and Transplant Association - European Renal Association. European Dialysis and Transplant Association - European Renal Association. Congress,
E T Pierce, and
R J Grekin, and
D R Mouw
August 1986,
Acta physiologica Scandinavica,
E T Pierce, and
R J Grekin, and
D R Mouw
June 1985,
Microscopia electronica y biologia celular : organo oficial de las Sociedades Latinoamericana de Microscopia Electronica e Iberoamericana de Biologia Celular,
