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The efficacy of papain, a proteolytic enzyme made in the USSR, was studied alone and in combination with antibiotics, such as benzylpenicillin, streptomycin, chloramphenicol, tetracycline, erythromycin and novobiocin in treatment of mice with septicemia caused by antibiotic-resistant staphylococci. It was shown that the enzyme increased the chemotherapeutic efficacy of the antibiotics on the average by 50 per cent. When used alone in a dose of 0.1 mg per mouse papain prevented death in 20 per cent of animals. The high chemotherapeutic efficacy of the antibiotic combinations with papain allowed recommending it for use in clinical practice for the treatment of infections caused by antibiotic-resistant staphylococci.
G Sh Baskanchiladze, and
L A Khurtsilava, and
I A Gelovani, and
M V Asatiani, and
V I Rossinskii
April 1956,
La Revue du praticien,
G Sh Baskanchiladze, and
L A Khurtsilava, and
I A Gelovani, and
M V Asatiani, and
V I Rossinskii
April 1961,
Antibiotics & chemotherapy (Northfield, Ill.),
G Sh Baskanchiladze, and
L A Khurtsilava, and
I A Gelovani, and
M V Asatiani, and
V I Rossinskii
September 1976,
Antibiotiki,
G Sh Baskanchiladze, and
L A Khurtsilava, and
I A Gelovani, and
M V Asatiani, and
V I Rossinskii
December 1994,
Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic],
G Sh Baskanchiladze, and
L A Khurtsilava, and
I A Gelovani, and
M V Asatiani, and
V I Rossinskii
January 1991,
Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic],
G Sh Baskanchiladze, and
L A Khurtsilava, and
I A Gelovani, and
M V Asatiani, and
V I Rossinskii
January 1980,
Infection,
G Sh Baskanchiladze, and
L A Khurtsilava, and
I A Gelovani, and
M V Asatiani, and
V I Rossinskii
August 1972,
Casopis lekaru ceskych,
G Sh Baskanchiladze, and
L A Khurtsilava, and
I A Gelovani, and
M V Asatiani, and
V I Rossinskii
January 1967,
Meditsinskaia parazitologiia i parazitarnye bolezni,
G Sh Baskanchiladze, and
L A Khurtsilava, and
I A Gelovani, and
M V Asatiani, and
V I Rossinskii
January 1977,
Annali Sclavo; rivista di microbiologia e di immunologia,
G Sh Baskanchiladze, and
L A Khurtsilava, and
I A Gelovani, and
M V Asatiani, and
V I Rossinskii
April 1979,
Antibiotiki,
