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In an attempt to evaluate the responsiveness of the serotonergic neurotransmitter system in depression, fenfluramine, a serotonin releasing agent, was administered to 18 depressed patients and 10 controls, and placebo was administered to 16 of the depressed patients in a double-blind paradigm. Plasma prolactin levels were measured prior to and for five hours following fenfluramine. Fenfluramine produced a significant increase in prolactin in both patients and controls. However, the prolactin response to fenfluramine whether measured as an absolute increase or percent increase from baseline was significantly less in depressed patients than controls. This difference remained equally statistically significant when age-and-sex-matched pairs of depressed patients and controls were compared. These results suggest that the central serotonergic system is less responsive in depressed patients than controls.
L J Siever, and
D L Murphy, and
S Slater, and
E de la Vega, and
S Lipper
August 1991,
The American journal of psychiatry,
L J Siever, and
D L Murphy, and
S Slater, and
E de la Vega, and
S Lipper
August 2002,
European archives of psychiatry and clinical neuroscience,
L J Siever, and
D L Murphy, and
S Slater, and
E de la Vega, and
S Lipper
December 1993,
Biological psychiatry,
L J Siever, and
D L Murphy, and
S Slater, and
E de la Vega, and
S Lipper
May 1978,
European journal of pharmacology,
L J Siever, and
D L Murphy, and
S Slater, and
E de la Vega, and
S Lipper
January 1991,
Progress in neuro-psychopharmacology & biological psychiatry,
L J Siever, and
D L Murphy, and
S Slater, and
E de la Vega, and
S Lipper
August 1995,
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology,
L J Siever, and
D L Murphy, and
S Slater, and
E de la Vega, and
S Lipper
February 1992,
The British journal of psychiatry : the journal of mental science,
L J Siever, and
D L Murphy, and
S Slater, and
E de la Vega, and
S Lipper
January 2011,
Neuropsychobiology,
L J Siever, and
D L Murphy, and
S Slater, and
E de la Vega, and
S Lipper
April 1993,
Biological psychiatry,
L J Siever, and
D L Murphy, and
S Slater, and
E de la Vega, and
S Lipper
April 1984,
Archives of general psychiatry,
