Biomaterial Database

Effect of nicotine chewing gum on plasma nicotine levels of cigarette smokers. 1984

R V Ebert, and M E McNabb, and S L Snow

This study was designed to determine whether the use of nicotine chewing gum modifies the inhalation and absorption of nicotine by cigarette smokers. Our subjects, 12 subjects who smoked cigarettes regularly, were studied for 4 days. On the first day, they smoked as usual, and on the second, third, and fourth days they also chewed a placebo gum, 2-mg nicotine gum, or 4-mg nicotine gum. They were instructed to smoke as usual throughout the study. Mean plasma nicotine concentration was 29.5 ng/ml with the placebo gum, 30.9 ng/ml with the 2-mg gum, and 40.7 ng/ml with the 4-mg gum. Peak carbon monoxide level was lower with nicotine gum than with placebo gum. Data indicate self-regulation of blood nicotine levels. The subjects appear to have compensated almost completely for the increased intake of nicotine from the 2-mg nicotine gum by decreasing the inhalation of tobacco smoke. Nicotine compensation provided by the 4-mg nicotine gum is only partial.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D008875	Middle Aged	An adult aged 45 - 64 years.	Middle Age
D009538	Nicotine	Nicotine is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimulates neurons and ultimately blocks synaptic transmission. Nicotine is also important medically because of its presence in tobacco smoke.	Nicotine Bitartrate,Nicotine Tartrate
D002248	Carbon Monoxide	Carbon monoxide (CO). A poisonous colorless, odorless, tasteless gas. It combines with hemoglobin to form carboxyhemoglobin, which has no oxygen carrying capacity. The resultant oxygen deprivation causes headache, dizziness, decreased pulse and respiratory rates, unconsciousness, and death. (From Merck Index, 11th ed)	Monoxide, Carbon
D002638	Chewing Gum	A preparation of chicle, sometimes mixed with other plastic substances, sweetened and flavored. It is masticated usually for pleasure as a candy substitute but it sometimes acts as a vehicle for the administration of medication.	Chewing Gums,Gum, Chewing,Gums, Chewing
D004305	Dose-Response Relationship, Drug	The relationship between the dose of an administered drug and the response of the organism to the drug.	Dose Response Relationship, Drug,Dose-Response Relationships, Drug,Drug Dose-Response Relationship,Drug Dose-Response Relationships,Relationship, Drug Dose-Response,Relationships, Drug Dose-Response
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000042	Absorption	The physical or physiological processes by which substances, tissue, cells, etc. take up or take in other substances or energy.
D000284	Administration, Oral	The giving of drugs, chemicals, or other substances by mouth.	Drug Administration, Oral,Administration, Oral Drug,Oral Administration,Oral Drug Administration,Administrations, Oral,Administrations, Oral Drug,Drug Administrations, Oral,Oral Administrations,Oral Drug Administrations
D012907	Smoking	Willful or deliberate act of inhaling and exhaling SMOKE from burning substances or agents held by hand.	Smoking Behaviors,Smoking Habit,Behavior, Smoking,Behaviors, Smoking,Habit, Smoking,Habits, Smoking,Smoking Behavior,Smoking Habits