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In a therapy-resistant epileptic population with partial complex seizures with or without secondary generalization, addition of flunarizine to existing therapy was accompanied by a significant reduction in complex partial and tonic-clonic seizures. This result did not appear to be due to serial effects or changes in the plasma levels of the co-medication. Side effects were rare. The serum flunarizine levels (13.8 ng/ml; range, 3-32.5 ng/ml) were lower than previously reported on a daily dose of 10 mg. This may reflect increased metabolism due to induction of liver enzymes by the co-medication. Given this finding, together with the low incidence of side effects, a further study is required to determine whether higher blood levels would give an improved degree and incidence of seizure reduction.
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A Wauquier
July 1991,
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A Wauquier
January 1996,
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A Wauquier
January 1994,
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A Wauquier
June 1988,
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J Overweg, and
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A Wauquier
February 1989,
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J Overweg, and
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J W Meijer, and
H Meinardi, and
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A Wauquier
January 1994,
Epilepsia,
J Overweg, and
C D Binnie, and
J W Meijer, and
H Meinardi, and
S T Nuijten, and
S Schmaltz, and
A Wauquier
January 1991,
Epilepsia,
J Overweg, and
C D Binnie, and
J W Meijer, and
H Meinardi, and
S T Nuijten, and
S Schmaltz, and
A Wauquier
May 1989,
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J Overweg, and
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A Wauquier
August 1990,
Epilepsy research,
