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The effects of negative pressure applied to just the upper airway on nasal and laryngeal muscle activity were studied in 14 spontaneously breathing anesthetized dogs. Moving average electromyograms were recorded from the alae nasi (AN) and posterior cricoarytenoid (PCA) muscles and compared with those of the genioglossus (GG) and diaphragm. The duration of inspiration and the length of inspiratory activity of all upper airway muscles was increased in a graded manner proportional to the amount of negative pressure applied. Phasic activation of upper airway muscles preceded inspiratory activity of the diaphragm under control conditions; upper airway negative pressure increased this amount of preactivation. Peak diaphragm activity was unchanged with negative pressure, although the rate of rise of muscle activity decreased. The average increases in peak upper airway muscle activity in response to all levels of negative pressure were 18 +/- 4% for the AN, 27 +/- 7% for the PCA, and 122 +/- 31% for the GG (P less than 0.001). Rates of rise of AN and PCA electrical activity increased at higher levels of negative pressure. Nasal negative pressure affected the AN more than the PCA, while laryngeal negative pressure had the opposite effect. The effects of nasal negative pressure could be abolished by topical anesthesia of the nasal passages, while the effects of laryngeal negative pressure could be abolished by either topical anesthesia of the larynx or section of the superior laryngeal nerve. Electrical stimulation of the superior laryngeal nerve caused depression of AN and PCA activity, and hence does not reproduce the effects of negative pressure.(ABSTRACT TRUNCATED AT 250 WORDS)
E van Lunteren, and
W B Van de Graaff, and
D M Parker, and
J Mitra, and
M A Haxhiu, and
K P Strohl, and
N S Cherniack
October 1988,
Respiration physiology,
E van Lunteren, and
W B Van de Graaff, and
D M Parker, and
J Mitra, and
M A Haxhiu, and
K P Strohl, and
N S Cherniack
March 1989,
Journal of applied physiology (Bethesda, Md. : 1985),
E van Lunteren, and
W B Van de Graaff, and
D M Parker, and
J Mitra, and
M A Haxhiu, and
K P Strohl, and
N S Cherniack
April 2003,
Journal of applied physiology (Bethesda, Md. : 1985),
E van Lunteren, and
W B Van de Graaff, and
D M Parker, and
J Mitra, and
M A Haxhiu, and
K P Strohl, and
N S Cherniack
July 2018,
The Journal of physiology,
E van Lunteren, and
W B Van de Graaff, and
D M Parker, and
J Mitra, and
M A Haxhiu, and
K P Strohl, and
N S Cherniack
August 1989,
Journal of applied physiology (Bethesda, Md. : 1985),
E van Lunteren, and
W B Van de Graaff, and
D M Parker, and
J Mitra, and
M A Haxhiu, and
K P Strohl, and
N S Cherniack
January 1985,
Journal of applied physiology (Bethesda, Md. : 1985),
E van Lunteren, and
W B Van de Graaff, and
D M Parker, and
J Mitra, and
M A Haxhiu, and
K P Strohl, and
N S Cherniack
November 1985,
Respiration physiology,
E van Lunteren, and
W B Van de Graaff, and
D M Parker, and
J Mitra, and
M A Haxhiu, and
K P Strohl, and
N S Cherniack
May 1991,
The Journal of physiology,
E van Lunteren, and
W B Van de Graaff, and
D M Parker, and
J Mitra, and
M A Haxhiu, and
K P Strohl, and
N S Cherniack
June 2007,
The Journal of physiology,
E van Lunteren, and
W B Van de Graaff, and
D M Parker, and
J Mitra, and
M A Haxhiu, and
K P Strohl, and
N S Cherniack
June 1994,
Journal of applied physiology (Bethesda, Md. : 1985),
