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The role of the pituitary gland in the effects of treatment with phenobarbital, methylcholanthrene and morphine on hepatic drug metabolism in adult male and adult female rats has been investigated. A marked sex difference in the effects of treatment with these three compounds on hepatic drug metabolizing enzymes in intact adult rats was observed. No sex differences in the effects of phenobarbital methylcholanthrene or morphine on hepatic drug metabolizing enzymes were observed after treatment of hypophysectomized adult male and hypophysectomized adult female rats. The results indicate that the pituitary gland plays an important role in the determination of sex differences in the response of hepatic drug metabolizing enzymes to inducing agents.
M J Finnen, and
K A Hassall
August 2009,
Molecular pharmacology,
M J Finnen, and
K A Hassall
January 2000,
Chemico-biological interactions,
M J Finnen, and
K A Hassall
May 1975,
Research communications in chemical pathology and pharmacology,
M J Finnen, and
K A Hassall
February 1975,
Biochemical pharmacology,
M J Finnen, and
K A Hassall
January 1990,
International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition,
M J Finnen, and
K A Hassall
April 1985,
Acta pharmacologica et toxicologica,
M J Finnen, and
K A Hassall
January 1979,
Drug metabolism and disposition: the biological fate of chemicals,
M J Finnen, and
K A Hassall
January 1988,
Polish journal of pharmacology and pharmacy,
M J Finnen, and
K A Hassall
January 1988,
Progress in clinical and biological research,
M J Finnen, and
K A Hassall
June 1984,
The Indian journal of medical research,
