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To further characterize immunologic alterations found in thermally injured patients, a series of experiments dealing with lymphocyte immunoglobulin production were performed. Circulating immunoglobulin levels were measured, plasma antitetanus toxoid was quantitated, and lymphocytes were cultured and in vitro immunoglobulin production recorded. Postburn circulating immunoglobulins were initially depressed but returned to normal at a variable rate. We found a normal response to rechallenge with tetanus toxoid. However, culture of lymphocytes in vitro showed that lymphocytes from burned patients had an elevated spontaneous immunoglobulin production and no augmentation with mitogen stimulation. This alteration in immunoglobulin production was not found in a group of postoperative or trauma patients and appears to be unique to burned patients.
R M Shorr, and
W B Ershler, and
R L Gamelli
June 1969,
Lancet (London, England),
R M Shorr, and
W B Ershler, and
R L Gamelli
September 1986,
The Journal of trauma,
R M Shorr, and
W B Ershler, and
R L Gamelli
March 1969,
Lancet (London, England),
R M Shorr, and
W B Ershler, and
R L Gamelli
January 1974,
Anesthesie, analgesie, reanimation,
R M Shorr, and
W B Ershler, and
R L Gamelli
December 1986,
Polski tygodnik lekarski (Warsaw, Poland : 1960),
R M Shorr, and
W B Ershler, and
R L Gamelli
April 1978,
The Journal of parasitology,
R M Shorr, and
W B Ershler, and
R L Gamelli
January 1984,
Archivum immunologiae et therapiae experimentalis,
R M Shorr, and
W B Ershler, and
R L Gamelli
August 1993,
Masui. The Japanese journal of anesthesiology,
R M Shorr, and
W B Ershler, and
R L Gamelli
January 2003,
Revista da Sociedade Brasileira de Medicina Tropical,
R M Shorr, and
W B Ershler, and
R L Gamelli
April 1969,
Lancet (London, England),
