Biomaterial Database

Anaerobic metabolism of the respiratory muscles during exercise. 1984

B J Martin, and H I Chen, and M A Kolka

Although minute ventilation (VE) exhibits marked increases during heavy rhythmic exercise utilizing a large muscle mass, the extent to which this hyperpnea stresses the respiratory muscles remains controversial. In an attempt to resolve this matter, we measured arterial blood lactate concentration during seated isocapnic reproduction of peak exercise ventilation. This level of ventilation had previously been identified during a maximal 2-min treadmill run. We found that maintenance of peak exercise ventilation raised blood lactate 50% in subjects otherwise at rest (N = 8, P less than 0.01). This lactate rise occurred despite addition of CO2 to inspired gas in amounts sufficient to maintain arterial blood pH and PCO2 at resting levels, which suggests that achieving the high exercise ventilation associated with VO2max may require significant anaerobic metabolism by respiratory muscles.

UI	MeSH Term	Description	Entries
D007773	Lactates	Salts or esters of LACTIC ACID containing the general formula CH3CHOHCOOR.
D008297	Male		Males
D008451	Maximal Voluntary Ventilation	Measure of the maximum amount of air that can be breathed in and blown out over a sustained interval such as 15 or 20 seconds. Common abbreviations are MVV and MBC.	Maximal Breathing Capacity,MVV (Ventilation),Breathing Capacities, Maximal,Breathing Capacity, Maximal,Capacities, Maximal Breathing,Capacity, Maximal Breathing,Maximal Breathing Capacities,Maximal Voluntary Ventilations,Ventilation, Maximal Voluntary,Ventilations, Maximal Voluntary,Voluntary Ventilation, Maximal,Voluntary Ventilations, Maximal
D009132	Muscles	Contractile tissue that produces movement in animals.	Muscle Tissue,Muscle,Muscle Tissues,Tissue, Muscle,Tissues, Muscle
D010101	Oxygen Consumption	The rate at which oxygen is used by a tissue; microliters of oxygen STPD used per milligram of tissue per hour; the rate at which oxygen enters the blood from alveolar gas, equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body. (Stedman, 25th ed, p346)	Consumption, Oxygen,Consumptions, Oxygen,Oxygen Consumptions
D012119	Respiration	The act of breathing with the LUNGS, consisting of INHALATION, or the taking into the lungs of the ambient air, and of EXHALATION, or the expelling of the modified air which contains more CARBON DIOXIDE than the air taken in (Blakiston's Gould Medical Dictionary, 4th ed.). This does not include tissue respiration (	Breathing
D005082	Physical Exertion	Expenditure of energy during PHYSICAL ACTIVITY. Intensity of exertion may be measured by rate of OXYGEN CONSUMPTION; HEAT produced, or HEART RATE. Perceived exertion, a psychological measure of exertion, is included.	Physical Effort,Effort, Physical,Efforts, Physical,Exertion, Physical,Exertions, Physical,Physical Efforts,Physical Exertions
D005260	Female		Females
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D006863	Hydrogen-Ion Concentration	The normality of a solution with respect to HYDROGEN ions; H+. It is related to acidity measurements in most cases by pH	pH,Concentration, Hydrogen-Ion,Concentrations, Hydrogen-Ion,Hydrogen Ion Concentration,Hydrogen-Ion Concentrations