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We studied serum vitamin E levels and the ratio of serum vitamin E to serum lipid levels in 11 children with chronic cholestasis complicated by vitamin E deficiency, as defined by characteristic neurologic signs or sural-nerve histopathology in addition to impaired intestinal absorption of vitamin E. Eight of the children had low levels of serum vitamin E, as well as low ratios of serum vitamin E to total lipids and to cholesterol. However, three patients had normal serum vitamin E levels but low ratios of serum vitamin E to total lipids (two of the three had normal ratios of vitamin E to cholesterol). In four patients who were not vitamin E-deficient, all three values were normal. We conclude that vitamin E deficiency may exist in a child with a normal serum vitamin E concentration and that the ratio of serum vitamin E to total serum lipids is the most reliable biochemical index of vitamin E status during chronic childhood cholestasis.
R J Sokol, and
J E Heubi, and
S T Iannaccone, and
K E Bove, and
W F Balistreri
August 1984,
Nutrition reviews,
R J Sokol, and
J E Heubi, and
S T Iannaccone, and
K E Bove, and
W F Balistreri
December 2016,
Journal of pediatric gastroenterology and nutrition,
R J Sokol, and
J E Heubi, and
S T Iannaccone, and
K E Bove, and
W F Balistreri
March 1983,
Annals of neurology,
R J Sokol, and
J E Heubi, and
S T Iannaccone, and
K E Bove, and
W F Balistreri
February 1987,
American journal of diseases of children (1960),
R J Sokol, and
J E Heubi, and
S T Iannaccone, and
K E Bove, and
W F Balistreri
January 1996,
Revista de gastroenterologia de Mexico,
R J Sokol, and
J E Heubi, and
S T Iannaccone, and
K E Bove, and
W F Balistreri
August 1982,
Proceedings of the National Academy of Sciences of the United States of America,
R J Sokol, and
J E Heubi, and
S T Iannaccone, and
K E Bove, and
W F Balistreri
April 1983,
The Journal of pediatrics,
R J Sokol, and
J E Heubi, and
S T Iannaccone, and
K E Bove, and
W F Balistreri
January 1982,
The Journal of pediatrics,
R J Sokol, and
J E Heubi, and
S T Iannaccone, and
K E Bove, and
W F Balistreri
May 1987,
Journal of neurology, neurosurgery, and psychiatry,
R J Sokol, and
J E Heubi, and
S T Iannaccone, and
K E Bove, and
W F Balistreri
January 1982,
Acta vitaminologica et enzymologica,
