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In this study, 10 mongrel dogs were anesthetized with sodium pentobarbital and nitrous oxide. Blood flow was determined using the radioactive microsphere technique before and after the bolus intravenous injection of naloxone (10 mg/kg). Naloxone significantly increased cerebral blood flow to cerebral cortex and the total cerebral hemisphere without an associated change in the cerebral metabolic rate of oxygen. The increase in cerebral blood flow was proportional to the elevation in mean arterial pressure. There were no consistent changes in electrical activity as measured by electroencephalography (EEG) and Fourier analysis of EEG. Systemically, naloxone induced a proportional rise in mean arterial pressure and peripheral vascular resistance and also stimulated the myocardium, as evidenced by an improved cardiac index and stroke volume. These data suggest that naloxone may interfere with cerebral autoregulation or have direct vasodilatory effects on cerebral blood vessels that are not associated with opiate receptor blockade or changes in cerebral metabolism. In addition, naloxone did not appear to reverse the cerebral depressive effects of pentobarbital. Systemically, naloxone seemed to potentiate pentobarbital-induced vasoconstriction and reverse myocardial depression.
D M Turner, and
N F Kassell, and
T Sasaki, and
Y G Comair, and
D O Beck, and
S L Klein
April 1965,
The American review of respiratory disease,
D M Turner, and
N F Kassell, and
T Sasaki, and
Y G Comair, and
D O Beck, and
S L Klein
October 1954,
The American journal of physiology,
D M Turner, and
N F Kassell, and
T Sasaki, and
Y G Comair, and
D O Beck, and
S L Klein
December 2009,
Journal of cardiovascular pharmacology,
D M Turner, and
N F Kassell, and
T Sasaki, and
Y G Comair, and
D O Beck, and
S L Klein
June 1985,
Naunyn-Schmiedeberg's archives of pharmacology,
D M Turner, and
N F Kassell, and
T Sasaki, and
Y G Comair, and
D O Beck, and
S L Klein
January 1977,
Comptes rendus des seances de la Societe de biologie et de ses filiales,
D M Turner, and
N F Kassell, and
T Sasaki, and
Y G Comair, and
D O Beck, and
S L Klein
March 1987,
The American journal of physiology,
D M Turner, and
N F Kassell, and
T Sasaki, and
Y G Comair, and
D O Beck, and
S L Klein
December 1983,
American journal of veterinary research,
D M Turner, and
N F Kassell, and
T Sasaki, and
Y G Comair, and
D O Beck, and
S L Klein
November 2000,
European journal of pharmacology,
D M Turner, and
N F Kassell, and
T Sasaki, and
Y G Comair, and
D O Beck, and
S L Klein
January 1982,
Pediatric pharmacology (New York, N.Y.),
D M Turner, and
N F Kassell, and
T Sasaki, and
Y G Comair, and
D O Beck, and
S L Klein
May 1994,
Anesthesia and analgesia,
