-transparent.png){kind=logo}
To study the possible involvement of hypothalamic vasoactive intestinal polypeptide (VIP) in regulating the secretion of prolactin (PRL), the effect of anti-VIP rabbit serum on serotonin (5-HT)-induced PRL release was examined in urethane-anesthetized male rats. Anti-VIP serum (AVS) or normal rabbit serum (NRS) was infused into a single hypophysial portal vessel of the rat for 40 min at a rate of 2 microliters/min with the aid of a fine glass cannula and 5-HT was injected into a lateral ventricle 10 min after the start of the infusion. Intraventricular injection of 5-HT (10 micrograms/rat) caused an increase in plasma PRL levels in control animals infused with NRS and 5-HT-induced PRL release was blunted in animals infused with AVS (mean +/- SE peak plasma PRL: 118.9 +/- 19.8 ng/ml vs 54.7 +/- 16.2 ng/ml, p less than 0.05). These findings suggest that the secretion of PRL induced by 5-HT is mediated, at least in part, by hypothalamic VIP release into the hypophysial portal blood in the rat.
A Shimatsu, and
Y Kato, and
H Ohta, and
K Tojo, and
Y Kabayama, and
T Inoue, and
N Yanaihara, and
H Imura
March 1987,
Neuroscience letters,
A Shimatsu, and
Y Kato, and
H Ohta, and
K Tojo, and
Y Kabayama, and
T Inoue, and
N Yanaihara, and
H Imura
December 1989,
Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine,
A Shimatsu, and
Y Kato, and
H Ohta, and
K Tojo, and
Y Kabayama, and
T Inoue, and
N Yanaihara, and
H Imura
August 1978,
Endocrinology,
A Shimatsu, and
Y Kato, and
H Ohta, and
K Tojo, and
Y Kabayama, and
T Inoue, and
N Yanaihara, and
H Imura
March 1995,
Nihon rinsho. Japanese journal of clinical medicine,
A Shimatsu, and
Y Kato, and
H Ohta, and
K Tojo, and
Y Kabayama, and
T Inoue, and
N Yanaihara, and
H Imura
June 2002,
Nihon rinsho. Japanese journal of clinical medicine,
A Shimatsu, and
Y Kato, and
H Ohta, and
K Tojo, and
Y Kabayama, and
T Inoue, and
N Yanaihara, and
H Imura
December 1999,
Nihon rinsho. Japanese journal of clinical medicine,
A Shimatsu, and
Y Kato, and
H Ohta, and
K Tojo, and
Y Kabayama, and
T Inoue, and
N Yanaihara, and
H Imura
July 2010,
Nihon rinsho. Japanese journal of clinical medicine,
A Shimatsu, and
Y Kato, and
H Ohta, and
K Tojo, and
Y Kabayama, and
T Inoue, and
N Yanaihara, and
H Imura
August 2005,
Nihon rinsho. Japanese journal of clinical medicine,
A Shimatsu, and
Y Kato, and
H Ohta, and
K Tojo, and
Y Kabayama, and
T Inoue, and
N Yanaihara, and
H Imura
August 1980,
Medical biology,
A Shimatsu, and
Y Kato, and
H Ohta, and
K Tojo, and
Y Kabayama, and
T Inoue, and
N Yanaihara, and
H Imura
March 1988,
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology,
