Biomaterial Database

Pathology of ochratoxicosis A in young broiler chicks. 1984

P Dwivedi, and R B Burns

Ochratoxin A (OA), a potent nephrotoxin, was fed in the diet in sublethal concentrations (2 and 4 ppm) to broiler chicks for 20 days from hatch. Its effects on growth, relative organ size and histology of the liver, kidney and lymphoid organs were investigated. In young broiler chicks, OA caused a significant enlargement of the kidney, liver and proventriculus, whereas the thymus and bursa of Fabricius were reduced in size. It principally affected the proximal convoluted tubules of the kidney causing severe distension, enlargement and hypertrophy, and it also resulted in thickening of the glomerular basement membrane. In the liver, vacuolation and glycogen accumulation in the hepatocytes were seen. The toxin also caused regression of and a drastic reduction in the lymphoid cell population in the immunological organs. The toxicity of OA was found to be dose related.

UI	MeSH Term	Description	Entries
D007668	Kidney	Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.	Kidneys
D008099	Liver	A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.	Livers
D009793	Ochratoxins	Isocoumarins found in ASPERGILLUS OCHRACEUS and other FUNGI. Ochratoxin contaminated FOOD has been responsible for cases of FOODBORNE DISEASES.	Ochratoxin
D009929	Organ Size	The measurement of an organ in volume, mass, or heaviness.	Organ Volume,Organ Weight,Size, Organ,Weight, Organ
D010581	Peyer's Patches	Lymphoid tissue on the mucosa of the small intestine.	Patches, Peyer's,Peyer Patches,Peyers Patches
D011201	Poultry Diseases	Diseases of birds which are raised as a source of meat or eggs for human consumption and are usually found in barnyards, hatcheries, etc. The concept is differentiated from BIRD DISEASES which is for diseases of birds not considered poultry and usually found in zoos, parks, and the wild.	Disease, Poultry,Diseases, Poultry,Poultry Disease
D001835	Body Weight	The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.	Body Weights,Weight, Body,Weights, Body
D002060	Bursa of Fabricius	An epithelial outgrowth of the cloaca in birds similar to the thymus in mammals. It atrophies within 6 months after birth and remains as a fibrous remnant in adult birds. It is composed of lymphoid tissue and prior to involution, is the site of B-lymphocyte maturation.	Fabricius Bursa
D002645	Chickens	Common name for the species Gallus gallus, the domestic fowl, in the family Phasianidae, order GALLIFORMES. It is descended from the red jungle fowl of SOUTHEAST ASIA.	Gallus gallus,Gallus domesticus,Gallus gallus domesticus,Chicken
D006243	Harderian Gland	A sebaceous gland that, in some animals, acts as an accessory to the lacrimal gland. The harderian gland excretes fluid that facilitates movement of the third eyelid.	Gland, Harderian