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Gross and microscopic lesions of experimental simian varicella (Delta herpesvirus) infection in African green monkeys (Cercopithecus aethiops) are described. In stratified squamous epithelium, such as the epidermis, tongue, and esophagus, focal areas of epidermal hyperplasia, ballooning degeneration, and blood-filled vesicle formation with ulceration were apparent. Most visceral organs were involved, and the changes included necrosis, hemorrhage, and characteristic intranuclear eosinophilic inclusions in a variety of cells. A generalized vascular involvement was present with intranuclear inclusions in the endothelial and smooth muscle cells in various organs. The nervous system was normal on gross and microscopic examination. Virus titer and serum transferase values were correlated with the clinical signs of infection.
E D Roberts, and
G B Baskin, and
K Soike, and
S V Gibson
June 1984,
Laboratory animal science,
E D Roberts, and
G B Baskin, and
K Soike, and
S V Gibson
June 1969,
The Kitasato archives of experimental medicine,
E D Roberts, and
G B Baskin, and
K Soike, and
S V Gibson
October 1980,
Laboratory animal science,
E D Roberts, and
G B Baskin, and
K Soike, and
S V Gibson
May 1979,
Veterinary pathology,
E D Roberts, and
G B Baskin, and
K Soike, and
S V Gibson
January 1988,
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E D Roberts, and
G B Baskin, and
K Soike, and
S V Gibson
November 1995,
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E D Roberts, and
G B Baskin, and
K Soike, and
S V Gibson
January 1973,
Archiv fur die gesamte Virusforschung,
E D Roberts, and
G B Baskin, and
K Soike, and
S V Gibson
December 1995,
Journal of medical primatology,
E D Roberts, and
G B Baskin, and
K Soike, and
S V Gibson
September 1987,
The American journal of tropical medicine and hygiene,
E D Roberts, and
G B Baskin, and
K Soike, and
S V Gibson
September 2002,
Journal of virology,
