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In a randomized prospective study we tested the toxicity and efficacy of recombinant alpha-2 interferon in the treatment of Kaposi's sarcoma associated with the acquired immunodeficiency syndrome. High doses (50 X 10(6) U/m2 body surface area, intravenously) or low doses (1 X 10(6) U/m2, subcutaneously) of recombinant alpha-2 interferon were administered to 20 patients for 5 days/wk, every other week, for four treatment cycles. Therapy was well tolerated subjectively and caused only mild hematologic and hepatic toxicity at both dose levels. No consistent or sustained changes were seen in immunologic variables during or after treatment. Six patients with Kaposi's sarcoma, four at high dose and two at low dose, had objective responses (complete or partial) to treatment. However, therapy did not appear to eradicate cytomegalovirus carriage or prevent opportunistic infections related to cytomegalovirus.
J E Groopman, and
M S Gottlieb, and
J Goodman, and
R T Mitsuyasu, and
M A Conant, and
H Prince, and
J L Fahey, and
M Derezin, and
W M Weinstein, and
C Casavante
January 1991,
International journal of immunopharmacology,
J E Groopman, and
M S Gottlieb, and
J Goodman, and
R T Mitsuyasu, and
M A Conant, and
H Prince, and
J L Fahey, and
M Derezin, and
W M Weinstein, and
C Casavante
January 1991,
Journal des maladies vasculaires,
J E Groopman, and
M S Gottlieb, and
J Goodman, and
R T Mitsuyasu, and
M A Conant, and
H Prince, and
J L Fahey, and
M Derezin, and
W M Weinstein, and
C Casavante
October 1990,
Journal of biological response modifiers,
J E Groopman, and
M S Gottlieb, and
J Goodman, and
R T Mitsuyasu, and
M A Conant, and
H Prince, and
J L Fahey, and
M Derezin, and
W M Weinstein, and
C Casavante
February 1991,
Journal of immunotherapy : official journal of the Society for Biological Therapy,
J E Groopman, and
M S Gottlieb, and
J Goodman, and
R T Mitsuyasu, and
M A Conant, and
H Prince, and
J L Fahey, and
M Derezin, and
W M Weinstein, and
C Casavante
March 1989,
Annals of internal medicine,
J E Groopman, and
M S Gottlieb, and
J Goodman, and
R T Mitsuyasu, and
M A Conant, and
H Prince, and
J L Fahey, and
M Derezin, and
W M Weinstein, and
C Casavante
October 1992,
Journal of the American Academy of Dermatology,
J E Groopman, and
M S Gottlieb, and
J Goodman, and
R T Mitsuyasu, and
M A Conant, and
H Prince, and
J L Fahey, and
M Derezin, and
W M Weinstein, and
C Casavante
February 1993,
Zhonghua Minguo wei sheng wu ji mian yi xue za zhi = Chinese journal of microbiology and immunology,
J E Groopman, and
M S Gottlieb, and
J Goodman, and
R T Mitsuyasu, and
M A Conant, and
H Prince, and
J L Fahey, and
M Derezin, and
W M Weinstein, and
C Casavante
May 1988,
Journal of clinical oncology : official journal of the American Society of Clinical Oncology,
J E Groopman, and
M S Gottlieb, and
J Goodman, and
R T Mitsuyasu, and
M A Conant, and
H Prince, and
J L Fahey, and
M Derezin, and
W M Weinstein, and
C Casavante
April 1985,
Journal of clinical oncology : official journal of the American Society of Clinical Oncology,
J E Groopman, and
M S Gottlieb, and
J Goodman, and
R T Mitsuyasu, and
M A Conant, and
H Prince, and
J L Fahey, and
M Derezin, and
W M Weinstein, and
C Casavante
September 1985,
Annals of internal medicine,
