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Thirty-seven patients with psoriatic arthritis were entered into a 12-week prospective, controlled, double-blind multicenter trial comparing placebo and oral pulse methotrexate therapy. Methotrexate was given in a dose of 2.5-5.0 mg every 12 hours in 3 consecutive doses per week. A stable background medication program with nonsteroidal antiinflammatory drugs was allowed. Methotrexate was superior to placebo only in physician assessment of arthritis activity and in improvement of the amount of skin surface area with psoriasis. A small but statistically significant rise of serum total bilirubin occurred in the methotrexate-treated patients. No patients were withdrawn from the study for adverse drug effects.
R F Willkens, and
H J Williams, and
J R Ward, and
M J Egger, and
J C Reading, and
P J Clements, and
E S Cathcart, and
C O Samuelson, and
M A Solsky, and
S B Kaplan
August 2012,
Rheumatology (Oxford, England),
R F Willkens, and
H J Williams, and
J R Ward, and
M J Egger, and
J C Reading, and
P J Clements, and
E S Cathcart, and
C O Samuelson, and
M A Solsky, and
S B Kaplan
January 2006,
The Journal of rheumatology,
R F Willkens, and
H J Williams, and
J R Ward, and
M J Egger, and
J C Reading, and
P J Clements, and
E S Cathcart, and
C O Samuelson, and
M A Solsky, and
S B Kaplan
April 2013,
Rheumatology (Oxford, England),
R F Willkens, and
H J Williams, and
J R Ward, and
M J Egger, and
J C Reading, and
P J Clements, and
E S Cathcart, and
C O Samuelson, and
M A Solsky, and
S B Kaplan
August 1990,
The Journal of rheumatology,
R F Willkens, and
H J Williams, and
J R Ward, and
M J Egger, and
J C Reading, and
P J Clements, and
E S Cathcart, and
C O Samuelson, and
M A Solsky, and
S B Kaplan
January 2024,
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R F Willkens, and
H J Williams, and
J R Ward, and
M J Egger, and
J C Reading, and
P J Clements, and
E S Cathcart, and
C O Samuelson, and
M A Solsky, and
S B Kaplan
June 2022,
Pain,
R F Willkens, and
H J Williams, and
J R Ward, and
M J Egger, and
J C Reading, and
P J Clements, and
E S Cathcart, and
C O Samuelson, and
M A Solsky, and
S B Kaplan
May 1995,
The Journal of rheumatology,
R F Willkens, and
H J Williams, and
J R Ward, and
M J Egger, and
J C Reading, and
P J Clements, and
E S Cathcart, and
C O Samuelson, and
M A Solsky, and
S B Kaplan
December 1997,
The Journal of clinical endocrinology and metabolism,
R F Willkens, and
H J Williams, and
J R Ward, and
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J C Reading, and
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E S Cathcart, and
C O Samuelson, and
M A Solsky, and
S B Kaplan
February 2020,
Trials,
R F Willkens, and
H J Williams, and
J R Ward, and
M J Egger, and
J C Reading, and
P J Clements, and
E S Cathcart, and
C O Samuelson, and
M A Solsky, and
S B Kaplan
June 1993,
Arthritis and rheumatism,
