-transparent.png){kind=logo}
A study was designed to investigate the effect of a fatty meal on the absorption of chlorophenoxyisobutyric acid (CPIB) in six healthy adult volunteers after oral administration of the p-chlorophenolic (PCP) ester of CPIB. Plasma concentrations of CPIB when administered with food were higher than those observed in the fasting state. The Cmax in the former case was 24.0 +/- 4.6 mg l-1 as against a value of 15.2 +/- 6.9 mg l-1 in the latter (P less than 0.01). The pharmacokinetic parameters measured were found to be linear with the dose administered. This could be due to low plasma concentrations of CPIB unable to cause a saturation of the plasma protein binding of this drug. It is concluded that a fatty meal enhances the absorption of this hypolipidaemic drug.
G Houin, and
R A Shastri, and
J Barre, and
B Pinchon, and
J P Tillement
June 1980,
Atherosclerosis,
G Houin, and
R A Shastri, and
J Barre, and
B Pinchon, and
J P Tillement
January 1988,
International journal of clinical pharmacology research,
G Houin, and
R A Shastri, and
J Barre, and
B Pinchon, and
J P Tillement
May 1979,
European journal of clinical pharmacology,
G Houin, and
R A Shastri, and
J Barre, and
B Pinchon, and
J P Tillement
January 1971,
Annali dell'Istituto superiore di sanita,
G Houin, and
R A Shastri, and
J Barre, and
B Pinchon, and
J P Tillement
June 1981,
Life sciences,
G Houin, and
R A Shastri, and
J Barre, and
B Pinchon, and
J P Tillement
April 1963,
The Medical journal of Australia,
G Houin, and
R A Shastri, and
J Barre, and
B Pinchon, and
J P Tillement
February 1971,
Circulation,
G Houin, and
R A Shastri, and
J Barre, and
B Pinchon, and
J P Tillement
October 1977,
International journal of clinical pharmacology and biopharmacy,
G Houin, and
R A Shastri, and
J Barre, and
B Pinchon, and
J P Tillement
September 1968,
Il Farmaco; edizione pratica,
G Houin, and
R A Shastri, and
J Barre, and
B Pinchon, and
J P Tillement
October 1969,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
