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Glomerular basement membrane synthesis was measured in vivo in diabetic rats at various times after streptozotocin injection. Simultaneously the type IV collagen concentration in serum was determined by a radioimmunoassay specific for the terminal cross-linking domain, 7S collagen. Basement membrane collagen synthesis and the 7S collagen levels were markedly raised in diabetic animals 18-34 days after streptozotocin injection and showed a significant correlation. The results suggest that the amount of serum 7S collagen reflects increased basement membrane synthesis in a diabetic situation. Both basement membrane collagen synthesis and serum 7S collagen concentration also show a positive correlation with the blood glucose levels of diabetic rats. This indicates that the degree of metabolic dysregulation influences basement membrane synthesis.
C Hasslacher, and
R Reichenbacher, and
F Gechter, and
R Timpl
October 1993,
Amino acids,
C Hasslacher, and
R Reichenbacher, and
F Gechter, and
R Timpl
February 1988,
Research communications in chemical pathology and pharmacology,
C Hasslacher, and
R Reichenbacher, and
F Gechter, and
R Timpl
December 1985,
Diabetologia,
C Hasslacher, and
R Reichenbacher, and
F Gechter, and
R Timpl
June 1985,
Nihon Jinzo Gakkai shi,
C Hasslacher, and
R Reichenbacher, and
F Gechter, and
R Timpl
May 1976,
The Journal of physiology,
C Hasslacher, and
R Reichenbacher, and
F Gechter, and
R Timpl
January 1993,
Advances in nephrology from the Necker Hospital,
C Hasslacher, and
R Reichenbacher, and
F Gechter, and
R Timpl
May 1987,
Diabetologia,
C Hasslacher, and
R Reichenbacher, and
F Gechter, and
R Timpl
January 1980,
Renal physiology,
C Hasslacher, and
R Reichenbacher, and
F Gechter, and
R Timpl
December 1999,
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society,
C Hasslacher, and
R Reichenbacher, and
F Gechter, and
R Timpl
January 1981,
Renal physiology,
