-transparent.png){kind=logo}
Kupffer cells in primary culture bind and endocytose rapidly added rat liver mitochondria. Using phase contrast microscopy various stages of the uptake and digestion of these organelles were documented. Activities of mitochondrial enzymes within the Kupffer cells increased during the early phase of phagocytosis; they later declined, reaching the endogenous level of the Kupffer cell mitochondria after 3 to 4 h. The uptake was enhanced in the presence of heparin or rat serum, while iodoacetate, cytochalasin B or anti-fibronectin antisera were inhibitory. The transient presence of enzymatically active hepatocyte mitochondria renders Kupffer cells capable of producing urea. This mechanism partially explains earlier observations of urea formation in non-parenchymal rat liver cells.
H Rieder, and
K Decker
May 1976,
Experimental cell research,
H Rieder, and
K Decker
October 1999,
Liver,
H Rieder, and
K Decker
September 1991,
Biomaterials,
H Rieder, and
K Decker
May 2012,
World journal of gastroenterology,
H Rieder, and
K Decker
June 1989,
Gastroenterology,
H Rieder, and
K Decker
April 1983,
European journal of biochemistry,
H Rieder, and
K Decker
June 1977,
Experimental cell research,
H Rieder, and
K Decker
May 1991,
FEBS letters,
H Rieder, and
K Decker
June 2005,
Toxicology,
H Rieder, and
K Decker
January 1981,
Acta biologica et medica Germanica,
