This article reports the successful surgical treatment of six patients who presented with prosthetic endocarditis and uncontrolled bacteremia. They were treated by replacement of the aortic root with a preserved homograft aortic valve. With this technique, ventricular-aortic continuity was established with a centrally flowing valve together with its attached aorta. The weakened aortic and the associated root abscess were thereby excluded from the high-anulus pressure systemic circulation. There were no operative deaths, and the longest postoperative survival time is 10 years. Two patients have conduction disturbance and symptoms relating to their malfunctioning aortic valves. The remaining four patients are all well at 5 years, 2 years, 9 months, and 6 months with no further evidence of infection. Homograft aortic root replacement is a suitable treatment for this potentially lethal condition.