-transparent.png){kind=logo}
The macromolecular polymer, methyl cellulose (MC), is a known hepatosplenomegalic agent which promotes a state of experimental hypersplenism in rats. This is characterized by massive splenomegaly, pancytopenia of the blood elements, medullary hypoplasia, and marked gross and histologic alteration of the liver, kidney, adrenals, and lungs. Massive splenomegaly results from storage of this inert material by splenic macrophages. In the present study, chronic MC administration in rats augmented the hepatic Ep response to hypoxia but did not appreciably affect renal production of Ep. Splenectomy resulted in a decrease in the extrarenal Ep response to hypoxia indicating a possible role of the massively enlarged spleen of these MC-treated rats in extrarenal Ep production. The augmentation of extrarenal Ep elaboration may be attributed to a stimulatory effect of MC on the hepatic and splenic macrophages.
G B Zuckerman, and
B A Naughton, and
A Gaito, and
R A Preti, and
A S Gordon
November 1976,
The Journal of laboratory and clinical medicine,
G B Zuckerman, and
B A Naughton, and
A Gaito, and
R A Preti, and
A S Gordon
March 1978,
Blood,
G B Zuckerman, and
B A Naughton, and
A Gaito, and
R A Preti, and
A S Gordon
May 1971,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
G B Zuckerman, and
B A Naughton, and
A Gaito, and
R A Preti, and
A S Gordon
April 1982,
The Journal of laboratory and clinical medicine,
G B Zuckerman, and
B A Naughton, and
A Gaito, and
R A Preti, and
A S Gordon
January 1971,
Israel journal of medical sciences,
G B Zuckerman, and
B A Naughton, and
A Gaito, and
R A Preti, and
A S Gordon
May 1979,
The Journal of laboratory and clinical medicine,
G B Zuckerman, and
B A Naughton, and
A Gaito, and
R A Preti, and
A S Gordon
August 1978,
Haematologica,
G B Zuckerman, and
B A Naughton, and
A Gaito, and
R A Preti, and
A S Gordon
February 1979,
Journal of the Reticuloendothelial Society,
G B Zuckerman, and
B A Naughton, and
A Gaito, and
R A Preti, and
A S Gordon
May 1979,
The Journal of laboratory and clinical medicine,
G B Zuckerman, and
B A Naughton, and
A Gaito, and
R A Preti, and
A S Gordon
June 1982,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
