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The precursors of ventricular fibrillation and asystole developing after ligation of a branch of the coronary artery and adrenalin injection were studied in 30 albino rats. The comparative efficacy of antiarrhythmic agents (ajmalin, lidocaine, isoptin, visken) in the prevention of ventricular fibrillation induced by electric current was determined in 40 rats. Ventricular extrasystole and tachysystole as well as the block of the bundle of His branch were the most common precursors of ventricular fibrillation. In some experiments fibrillation was preceded by complete atrioventricular block, cardiac fibrillation, sinus bradycardia, nonparoxysmal ventricular tachycardia, and excaped ventricular contractions. Ventricular asystole was most frequently preceded by complete atrioventricular block and the bundle of His branch block. Among the antiarrhythmic agents studied, ajmalin proved most effective in prevention of ventricular fibrillation; it raised the fibrillation threshold in all animals. Lidocaine, which produced a prophylactic effect in 50% of experiments, was second in effectiveness. Changes in the ventricular fibrillation threshold due to the effect of these agents were statistically significant on the average. Isoptin and visken proved to be less effective.
V L Doshchitsin, and
V M Pozin, and
S G Skuratovskaia, and
G E Gendlin, and
I F Fedorova
April 1978,
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V L Doshchitsin, and
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S G Skuratovskaia, and
G E Gendlin, and
I F Fedorova
April 1958,
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V L Doshchitsin, and
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S G Skuratovskaia, and
G E Gendlin, and
I F Fedorova
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Verhandlungen der Deutschen Gesellschaft fur Kreislaufforschung,
V L Doshchitsin, and
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S G Skuratovskaia, and
G E Gendlin, and
I F Fedorova
June 1956,
Munchener medizinische Wochenschrift (1950),
V L Doshchitsin, and
V M Pozin, and
S G Skuratovskaia, and
G E Gendlin, and
I F Fedorova
November 1959,
The Journal of thoracic and cardiovascular surgery,
V L Doshchitsin, and
V M Pozin, and
S G Skuratovskaia, and
G E Gendlin, and
I F Fedorova
August 1969,
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V L Doshchitsin, and
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S G Skuratovskaia, and
G E Gendlin, and
I F Fedorova
July 1957,
Arzneimittel-Forschung,
V L Doshchitsin, and
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S G Skuratovskaia, and
G E Gendlin, and
I F Fedorova
June 2011,
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology,
V L Doshchitsin, and
V M Pozin, and
S G Skuratovskaia, and
G E Gendlin, and
I F Fedorova
October 2000,
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology,
V L Doshchitsin, and
V M Pozin, and
S G Skuratovskaia, and
G E Gendlin, and
I F Fedorova
January 1984,
Zeitschrift fur experimentelle Chirurgie, Transplantation, und kunstliche Organe : Organ der Sektion Experimentelle Chirurgie der Gesellschaft fur Chirurgie der DDR,
