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The daily changes in the functional state of the cardiovascular system and in the indices of bioelectric activity and hemodynamics of the brain, as well as the daily variability of lipid metabolism, electrolytes and 17-OCS in urine and certain indices of hemostasis were studied in 162 patients with ischemic heart disease. It was shown that, as compared to healthy individuals, patients with ischemic heart disease had a smaller amplitude of fluctuations in the daily rhythm with displacement of the peaks of activity to a later time. The only exception was the daily excretion of 17-OCS and aldosterone, the amplitude of fluctuations of which was close to that of these indices in healthy individuals but was distinguished by a displacement of 4 hrs. It is concluded that the biological clocks are sensitive to the changing conditions in which the systems of the organism function in ischemic heart disease.
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