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Ten fasting subjects received 200 mg cimetidine orally either with water or 11 g aluminium phosphate mixture in a randomized, single dose, two-way cross-over study. Blood samples were taken for 12 h and urine was collected for 24 h. Cimetidine in plasma and urine was analysed by HPLC. There were no significant differences between the treatments with respect to peak plasma concentration, time to peak plasma concentration, area under the plasma concentration-time curve, and urinary excretion. In 12 healthy subjects the absorption of prednisolone was investigated when given alone and together with 11 g aluminium phosphate. Blood samples were taken over 16 h and prednisolone in plasma was analysed by HPLC. There were no significant differences in the values of area under curve (AUC), Cmax and tmax. The results indicate that aluminium phosphate does not reduce the bioavailability of cimetidine and prednisolone.
H Albin, and
G Vincon, and
F Demotes-Mainard, and
B Begaud, and
A Bedjaoui
January 1989,
Biopharmaceutics & drug disposition,
H Albin, and
G Vincon, and
F Demotes-Mainard, and
B Begaud, and
A Bedjaoui
January 1982,
Therapie,
H Albin, and
G Vincon, and
F Demotes-Mainard, and
B Begaud, and
A Bedjaoui
July 1980,
British journal of clinical pharmacology,
H Albin, and
G Vincon, and
F Demotes-Mainard, and
B Begaud, and
A Bedjaoui
January 1983,
Therapie,
H Albin, and
G Vincon, and
F Demotes-Mainard, and
B Begaud, and
A Bedjaoui
December 1995,
Journal of pharmaceutical sciences,
H Albin, and
G Vincon, and
F Demotes-Mainard, and
B Begaud, and
A Bedjaoui
September 1989,
Zhonghua nei ke za zhi,
H Albin, and
G Vincon, and
F Demotes-Mainard, and
B Begaud, and
A Bedjaoui
October 1991,
The CLAO journal : official publication of the Contact Lens Association of Ophthalmologists, Inc,
H Albin, and
G Vincon, and
F Demotes-Mainard, and
B Begaud, and
A Bedjaoui
January 1955,
Annales medicinae experimentalis et biologiae Fenniae,
H Albin, and
G Vincon, and
F Demotes-Mainard, and
B Begaud, and
A Bedjaoui
January 1983,
Clinical pharmacy,
H Albin, and
G Vincon, and
F Demotes-Mainard, and
B Begaud, and
A Bedjaoui
April 1982,
Pathologie-biologie,
