Metabolic implications in the elevation of serum activity of intestinal alkaline phosphatase in chronic renal failure. 1984

J Stĕpán, and T Havránek, and E Jelínková, and M Straková, and J Skrha, and V Pacovský

The activity of intestinal isoenzyme of serum alkaline phosphatase was evaluated in 21 non-dialyzed patients with advanced renal failure and in 52 patients on regular hemodialysis. In patients without hepatopathy, a significant inverse correlation was found between the enzyme activity and serum calcium levels. Hepatopathy was the most significant variable influencing the enzyme activity in patients on dialysis. Secondary hyperparathyroidism and a decreased rate in enzyme elimination should be assessed for the above-normal activities of intestinal ALP in serum in chronic renal failure.

UI MeSH Term Description Entries
D007422 Intestines The section of the alimentary canal from the STOMACH to the ANAL CANAL. It includes the LARGE INTESTINE and SMALL INTESTINE. Intestine
D007527 Isoenzymes Structurally related forms of an enzyme. Each isoenzyme has the same mechanism and classification, but differs in its chemical, physical, or immunological characteristics. Alloenzyme,Allozyme,Isoenzyme,Isozyme,Isozymes,Alloenzymes,Allozymes
D007676 Kidney Failure, Chronic The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the level of PROTEINURIA) and the reduction in GLOMERULAR FILTRATION RATE to less than 15 ml per min (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002). These patients generally require HEMODIALYSIS or KIDNEY TRANSPLANTATION. ESRD,End-Stage Renal Disease,Renal Disease, End-Stage,Renal Failure, Chronic,Renal Failure, End-Stage,Chronic Kidney Failure,End-Stage Kidney Disease,Chronic Renal Failure,Disease, End-Stage Kidney,Disease, End-Stage Renal,End Stage Kidney Disease,End Stage Renal Disease,End-Stage Renal Failure,Kidney Disease, End-Stage,Renal Disease, End Stage,Renal Failure, End Stage
D008099 Liver A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances. Livers
D008107 Liver Diseases Pathological processes of the LIVER. Liver Dysfunction,Disease, Liver,Diseases, Liver,Dysfunction, Liver,Dysfunctions, Liver,Liver Disease,Liver Dysfunctions
D001842 Bone and Bones A specialized CONNECTIVE TISSUE that is the main constituent of the SKELETON. The principal cellular component of bone is comprised of OSTEOBLASTS; OSTEOCYTES; and OSTEOCLASTS, while FIBRILLAR COLLAGENS and hydroxyapatite crystals form the BONE MATRIX. Bone Tissue,Bone and Bone,Bone,Bones,Bones and Bone,Bones and Bone Tissue,Bony Apophyses,Bony Apophysis,Condyle,Apophyses, Bony,Apophysis, Bony,Bone Tissues,Condyles,Tissue, Bone,Tissues, Bone
D002118 Calcium A basic element found in nearly all tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes. Coagulation Factor IV,Factor IV,Blood Coagulation Factor IV,Calcium-40,Calcium 40,Factor IV, Coagulation
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000469 Alkaline Phosphatase An enzyme that catalyzes the conversion of an orthophosphoric monoester and water to an alcohol and orthophosphate. EC 3.1.3.1.

Related Publications

J Stĕpán, and T Havránek, and E Jelínková, and M Straková, and J Skrha, and V Pacovský
January 1988, Gastroenterology,
J Stĕpán, and T Havránek, and E Jelínková, and M Straková, and J Skrha, and V Pacovský
October 1977, Clinica chimica acta; international journal of clinical chemistry,
J Stĕpán, and T Havránek, and E Jelínková, and M Straková, and J Skrha, and V Pacovský
March 2002, Kidney international,
J Stĕpán, and T Havránek, and E Jelínková, and M Straková, and J Skrha, and V Pacovský
April 1985, Deutsche medizinische Wochenschrift (1946),
J Stĕpán, and T Havránek, and E Jelínková, and M Straková, and J Skrha, and V Pacovský
November 1984, The Journal of pediatrics,
J Stĕpán, and T Havránek, and E Jelínková, and M Straková, and J Skrha, and V Pacovský
March 1998, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association,
J Stĕpán, and T Havránek, and E Jelínková, and M Straková, and J Skrha, and V Pacovský
May 1985, JAMA,
J Stĕpán, and T Havránek, and E Jelínková, and M Straková, and J Skrha, and V Pacovský
July 1967, American journal of clinical pathology,
J Stĕpán, and T Havránek, and E Jelínková, and M Straková, and J Skrha, and V Pacovský
February 1977, Clinical biochemistry,
J Stĕpán, and T Havránek, and E Jelínková, and M Straková, and J Skrha, and V Pacovský
September 2012, BMC neurology,
Copied contents to your clipboard!