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Although the immunoregulatory role of iron has been demonstrated in vitro, evidence for a similar role in vivo is controversial. We have, therefore, studied certain functional and structural properties of lymphocytes in hereditary (idiopathic) hemochromatosis (HH), a disease characterized by iron overload. T- and B-lymphocyte percentages in peripheral blood, serum immunoglobulin levels, and proliferative responses of peripheral blood mononuclear cells (PBM) to lectins were comparable with those of controls. Furthermore, HH serum with elevated iron concentrations did not significantly alter proliferative responses of normal lymphocytes to mitogens. In contrast to those normal findings was the identification of a subset of T lymphocytes in HH that formed rosettes with sheep red blood cells (SRC) at 37 degrees C in abnormally high numbers. Those lymphocytes that formed thermostable erythrocyte rosettes (TE-R) were not immature thymocytes, activated T lymphocytes, or an artifact of passive attachment of anti-SRC antibodies to the HH lymphocyte surface. Their presence did not correlate with a concentration of iron in the serum, the length of treatment, or the presence of the HLA antigen, A3. We conclude that the cellular expression of HH may be detected not as an immunological abnormality, but rather as an abnormality in receptor expression.
C F Bryan, and
S H Leech, and
R Ducos, and
C Q Edwards, and
J P Kushner, and
M H Skolnick, and
B Bozelka, and
J C Linn, and
R Gaumer
July 1974,
Experientia,
C F Bryan, and
S H Leech, and
R Ducos, and
C Q Edwards, and
J P Kushner, and
M H Skolnick, and
B Bozelka, and
J C Linn, and
R Gaumer
November 1977,
American journal of veterinary research,
C F Bryan, and
S H Leech, and
R Ducos, and
C Q Edwards, and
J P Kushner, and
M H Skolnick, and
B Bozelka, and
J C Linn, and
R Gaumer
January 1978,
Boletin medico del Hospital Infantil de Mexico,
C F Bryan, and
S H Leech, and
R Ducos, and
C Q Edwards, and
J P Kushner, and
M H Skolnick, and
B Bozelka, and
J C Linn, and
R Gaumer
May 1983,
Dermatologische Monatschrift,
C F Bryan, and
S H Leech, and
R Ducos, and
C Q Edwards, and
J P Kushner, and
M H Skolnick, and
B Bozelka, and
J C Linn, and
R Gaumer
January 1985,
Allergie und Immunologie,
C F Bryan, and
S H Leech, and
R Ducos, and
C Q Edwards, and
J P Kushner, and
M H Skolnick, and
B Bozelka, and
J C Linn, and
R Gaumer
January 1977,
Boletin medico del Hospital Infantil de Mexico,
C F Bryan, and
S H Leech, and
R Ducos, and
C Q Edwards, and
J P Kushner, and
M H Skolnick, and
B Bozelka, and
J C Linn, and
R Gaumer
July 1980,
Zhurnal mikrobiologii, epidemiologii i immunobiologii,
C F Bryan, and
S H Leech, and
R Ducos, and
C Q Edwards, and
J P Kushner, and
M H Skolnick, and
B Bozelka, and
J C Linn, and
R Gaumer
February 1983,
Clinical immunology and immunopathology,
C F Bryan, and
S H Leech, and
R Ducos, and
C Q Edwards, and
J P Kushner, and
M H Skolnick, and
B Bozelka, and
J C Linn, and
R Gaumer
January 1981,
Comparative immunology, microbiology and infectious diseases,
C F Bryan, and
S H Leech, and
R Ducos, and
C Q Edwards, and
J P Kushner, and
M H Skolnick, and
B Bozelka, and
J C Linn, and
R Gaumer
January 1979,
Neoplasma,
