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Specific binding sites for arginine-vasopressin (AVP) were detected in rat brain after incubation of tissue sections with [3H]AVP. AVP and two selective AVP antagonists are capable of displacing [3H]AVP with an IC50 in the 10(-8)-10(-7) molar range, while oxytocin and ACTH4-10 were much less effective. The neuroanatomical distribution of [3H]AVP-labeled sites was studied with autoradiography utilizing tritium-sensitive LKB film and computerized densitometry for quantitative analyses of the film images. The highest density of [3H]AVP binding sites was observed in hippocampal regions, the lateral septum, olfactory and amygdaloid nuclei, and the nucleus tractus solitarii (NTS) of the brainstem.
A Biegon, and
M Terlou, and
T D Voorhuis, and
E R de Kloet
April 1983,
Life sciences,
A Biegon, and
M Terlou, and
T D Voorhuis, and
E R de Kloet
April 1988,
Brain research,
A Biegon, and
M Terlou, and
T D Voorhuis, and
E R de Kloet
February 1989,
Brain research,
A Biegon, and
M Terlou, and
T D Voorhuis, and
E R de Kloet
October 1983,
Neuroscience letters,
A Biegon, and
M Terlou, and
T D Voorhuis, and
E R de Kloet
May 1985,
Neuroscience letters,
A Biegon, and
M Terlou, and
T D Voorhuis, and
E R de Kloet
August 1989,
European journal of pharmacology,
A Biegon, and
M Terlou, and
T D Voorhuis, and
E R de Kloet
June 1989,
Journal of protein chemistry,
A Biegon, and
M Terlou, and
T D Voorhuis, and
E R de Kloet
September 1985,
Neurochemical research,
A Biegon, and
M Terlou, and
T D Voorhuis, and
E R de Kloet
December 1988,
Cellular and molecular neurobiology,
A Biegon, and
M Terlou, and
T D Voorhuis, and
E R de Kloet
January 1989,
Chronobiology international,
