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Chromosomal morphology from cultured peripheral lymphocytes was studied in 81 men; 57 of the men were employed on plants manufacturing vinyl chloride or polyvinylchloride, 19 were on-site controls and 5 were off-site controls. There was a significant increase in chromosomal abnormalities in the exposed workers when compared with the controls. The greatest statistically significant increase in total B and total C cells occurred in autoclave operators, with smaller increases in other job categories. The increase in chromosomal aberrations was correlated with the length of exposure and with a history during the year prior to sampling (1973--1974) of exposure to excursion levels of vinyl chloride. Information on smoking habits was obtained 18 months after blood sampling and a positive correlation between these and total C cell abnormalities was found. There was no positive correlation with various other parameters (bilirubin, platelets, gamma-glutamyltranspeptidase, alkaline phosphatase, alanine transaminase and aspartate transaminase). It was not possible to estimate which of the three parameters (smoking history, length of employment or exposure to excursion levels) was the most important.
I F Purchase, and
C R Richardson, and
D Anderson, and
G M Paddle, and
W G Adams
August 2011,
Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases,
I F Purchase, and
C R Richardson, and
D Anderson, and
G M Paddle, and
W G Adams
January 1998,
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals,
I F Purchase, and
C R Richardson, and
D Anderson, and
G M Paddle, and
W G Adams
January 1981,
Journal of hygiene, epidemiology, microbiology, and immunology,
I F Purchase, and
C R Richardson, and
D Anderson, and
G M Paddle, and
W G Adams
June 1989,
Journal of occupational medicine. : official publication of the Industrial Medical Association,
I F Purchase, and
C R Richardson, and
D Anderson, and
G M Paddle, and
W G Adams
March 1983,
Ceskoslovenska neurologie a neurochirurgie,
I F Purchase, and
C R Richardson, and
D Anderson, and
G M Paddle, and
W G Adams
November 2017,
Wei sheng yan jiu = Journal of hygiene research,
I F Purchase, and
C R Richardson, and
D Anderson, and
G M Paddle, and
W G Adams
January 1976,
Annals of the New York Academy of Sciences,
I F Purchase, and
C R Richardson, and
D Anderson, and
G M Paddle, and
W G Adams
December 2017,
Journal of occupational and environmental medicine,
I F Purchase, and
C R Richardson, and
D Anderson, and
G M Paddle, and
W G Adams
January 2006,
International archives of occupational and environmental health,
I F Purchase, and
C R Richardson, and
D Anderson, and
G M Paddle, and
W G Adams
December 1980,
Mutation research,
