Biomaterial Database

Metabolism and excretion of orally administered dimethylarsinic acid in the hamster. 1984

H Yamauchi, and Y Yamamura

We administered a single po dose of dimethylarsinic acid ( DMAA ) to hamsters by stomach tube and determined the in vivo accumulation of the arsenic and its excretion in the urine and feces. It was shown that a part of the DMAA was further methylated to a trimethylarsenic compound (TMA). During the 24 hr following the administration of DMAA , a total of 80% was excreted in the urine and feces: 45% in the urine (made up of 67.9% DMAA and 32.0% TMA), and 34.7% in the feces (almost completely made up of DMAA but no TMA). The findings show that DMAA and the TMA are rapidly excreted and do not accumulate in the body.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D008647	Mesocricetus	A genus in the order Rodentia and family Cricetidae. One species, Mesocricetus auratus or golden hamster is widely used in biomedical research.	Hamsters, Golden,Hamsters, Golden Syrian,Hamsters, Syrian,Mesocricetus auratus,Syrian Golden Hamster,Syrian Hamster,Golden Hamster,Golden Hamster, Syrian,Golden Hamsters,Golden Syrian Hamsters,Hamster, Golden,Hamster, Syrian,Hamster, Syrian Golden,Syrian Hamsters
D002101	Cacodylic Acid	An arsenical that has been used as a dermatologic agent and as an herbicide.	Cacodylate,Dimethylarsinate,Dimethylarsinic Acid,Acid, Cacodylic,Acid, Dimethylarsinic
D005243	Feces	Excrement from the INTESTINES, containing unabsorbed solids, waste products, secretions, and BACTERIA of the DIGESTIVE SYSTEM.
D006224	Cricetinae	A subfamily in the family MURIDAE, comprising the hamsters. Four of the more common genera are Cricetus, CRICETULUS; MESOCRICETUS; and PHODOPUS.	Cricetus,Hamsters,Hamster
D000284	Administration, Oral	The giving of drugs, chemicals, or other substances by mouth.	Drug Administration, Oral,Administration, Oral Drug,Oral Administration,Oral Drug Administration,Administrations, Oral,Administrations, Oral Drug,Drug Administrations, Oral,Oral Administrations,Oral Drug Administrations
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D001151	Arsenic	A shiny gray element with atomic symbol As, atomic number 33, and atomic weight 75. It occurs throughout the universe, mostly in the form of metallic arsenides. Most forms are toxic. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), arsenic and certain arsenic compounds have been listed as known carcinogens. (From Merck Index, 11th ed)	Arsenic-75,Arsenic 75
D001152	Arsenicals	Inorganic or organic compounds that contain arsenic.	Arsenic Compounds,Compounds, Arsenic