Biomaterial Database

[Ketotifen in the treatment of chronic urticaria and angioneurotic edema]. 1984

J Piñol, and F J Carapeto

26 male and female patients, suffering chronic idiopathic urticaria and angioneurotic edema, are treated with a new synthase molecule, Ketotifen, which offers a polivalent action. Among the patients there was a great majority of females (61,5%) their mean age being 35 years. The mean duration of this urticaria was 57,3 months, being even longer in male patients. In eleven of these cases there was a previous history of atopy in their families, and sixteen patients had some episodes of atopy in the past. All the patients were treated with ketotifen, in 1 mg. tablets, usually administered before meals, with partial doses no higher than 1 mg. 3 times a day, and a total dosage ranging from 28 to 180 mg. With this dosage we attained satisfactory results in 80,8% of the cases, with complete curation in 16 patients and a remarkable improvement of symptoms in 5 patients. In only two of the cases there was no response to the treatment. Tolerance to this drug was excellent in 88,6% of the patients. For all these reasons we consider ketotifen as an excellent therapeutic agent in Chronic Idiopathic Urticaria and Angioneurotic Edema, especially in those cases in which traditional therapies have failed. We also think that ketotifen, in association with other drugs, for example, terbutaline ( SAIHAN ) may solve, at least in some patients, the therapeutical problem that these conditions present. Furthermore, the nearly complete absence of important secondary effects, as observed in our study, makes it the treatment of choice in patients with gastric intolerance to drugs, or in those patients that, owing to their occupational activities, might be exposed to a high risk of laboral accidents.

UI	MeSH Term	Description	Entries
D006969	Hypersensitivity, Immediate	Hypersensitivity reactions which occur within minutes of exposure to challenging antigen due to the release of histamine which follows the antigen-antibody reaction and causes smooth muscle contraction and increased vascular permeability.	Atopic Hypersensitivity,Hypersensitivity, Atopic,Hypersensitivity, Type I,IgE-Mediated Hypersensitivity,Type I Hypersensitivity,Atopic Hypersensitivities,Hypersensitivities, Atopic,Hypersensitivities, IgE-Mediated,Hypersensitivities, Immediate,Hypersensitivities, Type I,Hypersensitivity, IgE-Mediated,IgE Mediated Hypersensitivity,IgE-Mediated Hypersensitivities,Immediate Hypersensitivities,Immediate Hypersensitivity,Type I Hypersensitivities
D007665	Ketotifen	A cycloheptathiophene blocker of histamine H1 receptors and release of inflammatory mediators. It has been proposed for the treatment of asthma, rhinitis, skin allergies, and anaphylaxis.	4,9-Dihydro-4-(1-methyl-4-piperidylidene)-10H-benzo(4,5)-cyclohepta(1,2-b)thiophen-10-one,Ketotifen Fumarate,Ketotifene,Ketotiphen,Ketotiphene,Zaditen,Fumarate, Ketotifen
D008297	Male		Males
D008875	Middle Aged	An adult aged 45 - 64 years.	Middle Age
D002648	Child	A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL.	Children
D002908	Chronic Disease	Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care (Dictionary of Health Services Management, 2d ed). For epidemiological studies chronic disease often includes HEART DISEASES; STROKE; CANCER; and diabetes (DIABETES MELLITUS, TYPE 2).	Chronic Condition,Chronic Illness,Chronically Ill,Chronic Conditions,Chronic Diseases,Chronic Illnesses,Condition, Chronic,Disease, Chronic,Illness, Chronic
D004341	Drug Evaluation	Any process by which toxicity, metabolism, absorption, elimination, preferred route of administration, safe dosage range, etc., for a drug or group of drugs is determined through clinical assessment in humans or veterinary animals.	Evaluation Studies, Drug,Drug Evaluation Studies,Drug Evaluation Study,Drug Evaluations,Evaluation Study, Drug,Evaluation, Drug,Evaluations, Drug,Studies, Drug Evaluation,Study, Drug Evaluation
D005260	Female		Females
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000284	Administration, Oral	The giving of drugs, chemicals, or other substances by mouth.	Drug Administration, Oral,Administration, Oral Drug,Oral Administration,Oral Drug Administration,Administrations, Oral,Administrations, Oral Drug,Drug Administrations, Oral,Oral Administrations,Oral Drug Administrations