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Familial associations of total cholesterol, low density lipoprotein cholesterol, triglycerides, and very low density lipoprotein cholesterol were examined in a population-based random sample of 858 white and 73 black probands and their 4,027 white and 245 black relatives from nine North American Lipid Research Clinics. Correlations among biologic relatives were highly significant for total cholesterol and low density lipoprotein cholesterol and to a lesser extent for triglycerides and very low density lipoprotein cholesterol in whites. Correlations for spouses, however, were not significant, suggesting a stronger influence of genes than shared environment in the determination of these traits. Homogeneity of familial correlations across age strata, clinics, and racial groups was examined. In general, correlations were homogeneous across age strata and clinics, and there was no asymmetry in parent-offspring correlations by the sex of the parent or offspring. Racial differences in correlations were not significant except in four of 32 comparisons, with blacks showing weaker correlations than whites in those instances.
K K Namboodiri, and
P P Green, and
E B Kaplan, and
J A Morrison, and
G A Chase, and
R C Elston, and
A R Owen, and
B M Rifkind, and
C J Glueck, and
H A Tyroler
January 1986,
Atherosclerosis,
K K Namboodiri, and
P P Green, and
E B Kaplan, and
J A Morrison, and
G A Chase, and
R C Elston, and
A R Owen, and
B M Rifkind, and
C J Glueck, and
H A Tyroler
June 1984,
American journal of epidemiology,
K K Namboodiri, and
P P Green, and
E B Kaplan, and
J A Morrison, and
G A Chase, and
R C Elston, and
A R Owen, and
B M Rifkind, and
C J Glueck, and
H A Tyroler
September 1981,
Circulation,
K K Namboodiri, and
P P Green, and
E B Kaplan, and
J A Morrison, and
G A Chase, and
R C Elston, and
A R Owen, and
B M Rifkind, and
C J Glueck, and
H A Tyroler
January 1991,
Human heredity,
K K Namboodiri, and
P P Green, and
E B Kaplan, and
J A Morrison, and
G A Chase, and
R C Elston, and
A R Owen, and
B M Rifkind, and
C J Glueck, and
H A Tyroler
June 1991,
American journal of medical genetics,
K K Namboodiri, and
P P Green, and
E B Kaplan, and
J A Morrison, and
G A Chase, and
R C Elston, and
A R Owen, and
B M Rifkind, and
C J Glueck, and
H A Tyroler
July 1985,
Clinical chemistry,
K K Namboodiri, and
P P Green, and
E B Kaplan, and
J A Morrison, and
G A Chase, and
R C Elston, and
A R Owen, and
B M Rifkind, and
C J Glueck, and
H A Tyroler
August 1979,
Circulation,
K K Namboodiri, and
P P Green, and
E B Kaplan, and
J A Morrison, and
G A Chase, and
R C Elston, and
A R Owen, and
B M Rifkind, and
C J Glueck, and
H A Tyroler
January 1988,
Genetic epidemiology,
K K Namboodiri, and
P P Green, and
E B Kaplan, and
J A Morrison, and
G A Chase, and
R C Elston, and
A R Owen, and
B M Rifkind, and
C J Glueck, and
H A Tyroler
June 1987,
American journal of human genetics,
K K Namboodiri, and
P P Green, and
E B Kaplan, and
J A Morrison, and
G A Chase, and
R C Elston, and
A R Owen, and
B M Rifkind, and
C J Glueck, and
H A Tyroler
November 1980,
Circulation,
