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The level of reduced glutathione in diabetic polymorphonuclear leukocytes was found to be significantly decreased compared to normal. Although the activity of glutathione reductase remained unchanged, the activity of glutathione peroxidase was found to be decreased in the diabetic state. Ketosis was not found to additionally aggravate the glutathione system. Polymorphonuclear leukocytes obtained from insulin-treated patients showed significant restoration.
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