Biomaterial Database

Totally implantable venous access system for cyclic administration of cytotoxic chemotherapy. 1984

K I Bland, and T Woodcock

Utilization of the totally implantable infusion system provides a convenient, cost-effective, and safe administration technique for oncology patients who require cyclic or continuous intravenous medication. In addition, it provides an excellent conduit for blood withdrawal access. The efficacy of this technique abrogates the necessity for periodic replacement of subclavian lines and their associated complications and possibly represents an advantage over percutaneous Broviac and Hickman catheters and the attendant catheter-related sepsis associated with their use. The initial low incidence of complications and absence of catheter thrombosis with this implantable system suggests its superiority over percutaneous silicone catheter devices for bolus drug injection and the continuous infusion of chemotherapeutic agents. Cyclic or continuous infusion of hypertonic dextrose and amino acid solutions (total parenteral nutrition) with this system is being evaluated but cannot yet be recommended as being more advantageous than infusion with an implanted Hickman or Broviac catheter.

UI	MeSH Term	Description	Entries
D007263	Infusions, Parenteral	The administration of liquid medication, nutrient, or other fluid through some other route than the alimentary canal, usually over minutes or hours, either by gravity flow or often by infusion pumping.	Intra-Abdominal Infusions,Intraperitoneal Infusions,Parenteral Infusions,Peritoneal Infusions,Infusion, Intra-Abdominal,Infusion, Intraperitoneal,Infusion, Parenteral,Infusion, Peritoneal,Infusions, Intra-Abdominal,Infusions, Intraperitoneal,Infusions, Peritoneal,Intra Abdominal Infusions,Intra-Abdominal Infusion,Intraperitoneal Infusion,Parenteral Infusion,Peritoneal Infusion
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000903	Antibiotics, Antineoplastic	Chemical substances, produced by microorganisms, inhibiting or preventing the proliferation of neoplasms.	Antineoplastic Antibiotics,Cytotoxic Antibiotics,Antibiotics, Cytotoxic
D013350	Subclavian Vein	The continuation of the axillary vein which follows the subclavian artery and then joins the internal jugular vein to form the brachiocephalic vein.	Subclavian Veins,Vein, Subclavian,Veins, Subclavian
D019736	Prostheses and Implants	Artificial substitutes for body parts, and materials inserted into tissue for functional, cosmetic, or therapeutic purposes. Prostheses can be functional, as in the case of artificial arms and legs, or cosmetic, as in the case of an artificial eye. Implants, all surgically inserted or grafted into the body, tend to be used therapeutically. IMPLANTS, EXPERIMENTAL is available for those used experimentally.	Implants, Artificial,Prostheses and Implant,Prosthesis,Prosthetic Implant,Endoprostheses,Endoprosthesis,Prostheses,Prosthetic Implants,Artificial Implant,Artificial Implants,Implant and Prostheses,Implant, Artificial,Implant, Prosthetic,Implants and Prostheses,Implants, Prosthetic