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The chemotherapeutic efficacy of gentamicin, tobramycin, sisomicin and dioxydin was studied and compared in rats with hematogenic obturation P. aeruginosa pyelonephritis. The drugs were injected intramuscularly in doses of 5, 8, 8 and 50 mg/kg, respectively for 7 days a day after infection. It was shown that on prolongation of the period of the treatment estimation from 24 hours to 7 days after discontinuation of the drug use a significant decrease was observed in the therapeutic efficacy of dioxydin, gentamicin and especially tobramycin. As for sisomicin, the decrease was insignificant. Dioxydin and gentamicin had a similar therapeutic effect at the early and late periods of their estimation after discontinuation of the treatment. They were inferior to tobramycin with respect to the early results and superior to it with respect to the late results. The chemotherapeutic efficacy of sisomycin in both the cases was higher than that of tobramycin, gentamicin and dioxydin.
T A Zinchenko, and
E A Rudzit, and
I B Zukakova, and
L I Lisitsa
January 1982,
Farmakologiia i toksikologiia,
T A Zinchenko, and
E A Rudzit, and
I B Zukakova, and
L I Lisitsa
April 1978,
Antibiotiki,
T A Zinchenko, and
E A Rudzit, and
I B Zukakova, and
L I Lisitsa
August 1970,
Orvosi hetilap,
T A Zinchenko, and
E A Rudzit, and
I B Zukakova, and
L I Lisitsa
January 1982,
Archivio per le scienze mediche,
T A Zinchenko, and
E A Rudzit, and
I B Zukakova, and
L I Lisitsa
March 2014,
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society,
T A Zinchenko, and
E A Rudzit, and
I B Zukakova, and
L I Lisitsa
May 2015,
Molecular pharmaceutics,
T A Zinchenko, and
E A Rudzit, and
I B Zukakova, and
L I Lisitsa
July 1975,
Antimicrobial agents and chemotherapy,
T A Zinchenko, and
E A Rudzit, and
I B Zukakova, and
L I Lisitsa
September 1977,
Antimicrobial agents and chemotherapy,
T A Zinchenko, and
E A Rudzit, and
I B Zukakova, and
L I Lisitsa
January 1978,
Infection,
T A Zinchenko, and
E A Rudzit, and
I B Zukakova, and
L I Lisitsa
September 1979,
The Medical journal of Australia,
