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Incubation of [3H]-sidechain-labeled and [14C]-C(4)-ring-labeled cyclophosphamide (CPA) with purified cytochrome P-450 from liver microsomes of rats treated with phenobarbital resulted in the production of a major metabolite that contained both labels, was unaffected by diazomethane, possessed high polarity, was identical in TLC and HPLC behavior to a synthetic standard, didechlorodihydroxy -CPA, and was converted to CPA and bis(2-chloroethyl)amine by thionyl chloride . These results indicate that phenobarbital-inducible cytochrome P-450 is able to dechlorinate CPA and may account, in part, for the inability of phenobarbital to enhance the therapeutic activity and toxicity of this important anticancer and immunosuppressive agent.
R F Struck, and
P Kari, and
J Kalin, and
J A Montgomery, and
A J Marinello, and
J Love, and
S K Bansal, and
H L Gurtoo
February 1987,
Xenobiotica; the fate of foreign compounds in biological systems,
R F Struck, and
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J A Montgomery, and
A J Marinello, and
J Love, and
S K Bansal, and
H L Gurtoo
April 1980,
Biochemical and biophysical research communications,
R F Struck, and
P Kari, and
J Kalin, and
J A Montgomery, and
A J Marinello, and
J Love, and
S K Bansal, and
H L Gurtoo
June 1987,
Rivista europea per le scienze mediche e farmacologiche = European review for medical and pharmacological sciences = Revue europeenne pour les sciences medicales et pharmacologiques,
R F Struck, and
P Kari, and
J Kalin, and
J A Montgomery, and
A J Marinello, and
J Love, and
S K Bansal, and
H L Gurtoo
November 1983,
Proceedings of the National Academy of Sciences of the United States of America,
R F Struck, and
P Kari, and
J Kalin, and
J A Montgomery, and
A J Marinello, and
J Love, and
S K Bansal, and
H L Gurtoo
October 1983,
The Biochemical journal,
R F Struck, and
P Kari, and
J Kalin, and
J A Montgomery, and
A J Marinello, and
J Love, and
S K Bansal, and
H L Gurtoo
October 1974,
Biochemical and biophysical research communications,
R F Struck, and
P Kari, and
J Kalin, and
J A Montgomery, and
A J Marinello, and
J Love, and
S K Bansal, and
H L Gurtoo
February 1983,
Biochemistry international,
R F Struck, and
P Kari, and
J Kalin, and
J A Montgomery, and
A J Marinello, and
J Love, and
S K Bansal, and
H L Gurtoo
September 1976,
The Kumamoto medical journal,
R F Struck, and
P Kari, and
J Kalin, and
J A Montgomery, and
A J Marinello, and
J Love, and
S K Bansal, and
H L Gurtoo
March 1989,
Chemical & pharmaceutical bulletin,
R F Struck, and
P Kari, and
J Kalin, and
J A Montgomery, and
A J Marinello, and
J Love, and
S K Bansal, and
H L Gurtoo
June 1975,
Biochemical and biophysical research communications,
