BIOMAT Database Logo BIOMAT Database Logo

Opposite effects of Met-enkephalin and Leu-enkephalin on a discriminated shock-escape task. 1984

J L Martinez, and K Olson, and C Hilston

Leu-enkephalin was found to impair and Met-enkephalin to enhance acquisition of a discriminated Y-maze shock-escape task in mice at equivalent doses (100 micrograms/kg, ip). Naloxone (1.0 and 10.0 mg/kg) also enhanced acquisition of the escape response and blocked the impairing actions of Leu-enkephalin. Neither naloxone nor the enkephalins influenced shock-induced locomotor activity in an open field. The results suggest that enkephalin actions on escape conditioning are mediated through opioid receptors.

UI MeSH Term Description Entries
D008297 Male Males
D009043 Motor Activity Body movements of a human or an animal as a behavioral phenomenon. Activities, Motor,Activity, Motor,Motor Activities
D009270 Naloxone A specific opiate antagonist that has no agonist activity. It is a competitive antagonist at mu, delta, and kappa opioid receptors. MRZ 2593-Br,MRZ-2593,Nalone,Naloxon Curamed,Naloxon-Ratiopharm,Naloxone Abello,Naloxone Hydrobromide,Naloxone Hydrochloride,Naloxone Hydrochloride Dihydride,Naloxone Hydrochloride, (5 beta,9 alpha,13 alpha,14 alpha)-Isomer,Naloxone, (5 beta,9 alpha,13 alpha,14 alpha)-Isomer,Narcan,Narcanti,Abello, Naloxone,Curamed, Naloxon,Dihydride, Naloxone Hydrochloride,Hydrobromide, Naloxone,Hydrochloride Dihydride, Naloxone,Hydrochloride, Naloxone,MRZ 2593,MRZ 2593 Br,MRZ 2593Br,MRZ2593,Naloxon Ratiopharm
D004193 Discrimination Learning Learning that is manifested in the ability to respond differentially to various stimuli. Discriminative Learning,Discrimination Learnings,Discriminative Learnings,Learning, Discrimination,Learning, Discriminative
D004305 Dose-Response Relationship, Drug The relationship between the dose of an administered drug and the response of the organism to the drug. Dose Response Relationship, Drug,Dose-Response Relationships, Drug,Drug Dose-Response Relationship,Drug Dose-Response Relationships,Relationship, Drug Dose-Response,Relationships, Drug Dose-Response
D004743 Enkephalin, Leucine One of the endogenous pentapeptides with morphine-like activity. It differs from MET-ENKEPHALIN in the LEUCINE at position 5. Its first four amino acid sequence is identical to the tetrapeptide sequence at the N-terminal of BETA-ENDORPHIN. Leucine Enkephalin,5-Leucine Enkephalin,Leu(5)-Enkephalin,Leu-Enkephalin,5 Leucine Enkephalin,Enkephalin, 5-Leucine,Leu Enkephalin
D004744 Enkephalin, Methionine One of the endogenous pentapeptides with morphine-like activity. It differs from LEU-ENKEPHALIN by the amino acid METHIONINE in position 5. Its first four amino acid sequence is identical to the tetrapeptide sequence at the N-terminal of BETA-ENDORPHIN. Methionine Enkephalin,5-Methionine Enkephalin,Met(5)-Enkephalin,Met-Enkephalin,5 Methionine Enkephalin,Enkephalin, 5-Methionine,Met Enkephalin
D004924 Escape Reaction Innate response elicited by sensory stimuli associated with a threatening situation, or actual confrontation with an enemy. Flight Reaction,Escape Reactions,Flight Reactions,Reaction, Escape,Reaction, Flight,Reactions, Escape,Reactions, Flight
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D051379 Mice The common name for the genus Mus. Mice, House,Mus,Mus musculus,Mice, Laboratory,Mouse,Mouse, House,Mouse, Laboratory,Mouse, Swiss,Mus domesticus,Mus musculus domesticus,Swiss Mice,House Mice,House Mouse,Laboratory Mice,Laboratory Mouse,Mice, Swiss,Swiss Mouse,domesticus, Mus musculus

Related Publications

J L Martinez, and K Olson, and C Hilston
Immunocytochemical and ultrastructural differentiation between Met-enkephalin-, Leu-enkephalin-, and Met/Leu-enkephalin-immunoreactive neurons of feline gut.
July 1982, The Journal of neuroscience : the official journal of the Society for Neuroscience,
J L Martinez, and K Olson, and C Hilston
[Methionine-enkephalin (Met-Enk) and leucine-enkephalin (Leu-Enk)].
August 2005, Nihon rinsho. Japanese journal of clinical medicine,
J L Martinez, and K Olson, and C Hilston
Antioxidative properties of Met- and Leu-enkephalin.
January 1990, Advances in experimental medicine and biology,
J L Martinez, and K Olson, and C Hilston
Enzymatic synthesis of Leu- and Met-enkephalin.
November 1979, Biochemical and biophysical research communications,
J L Martinez, and K Olson, and C Hilston
Effects of intravenously administered Leu- or Met-enkephalin on arterial blood pressure.
October 1980, Regulatory peptides,
J L Martinez, and K Olson, and C Hilston
Met-enkephalin-Arg6-Gly7-Leu8 exists together with Met-enkephalin-Arg6-Phe7, Met-enkephalin and Leu-enkephalin in human stomach.
January 1983, Life sciences,
J L Martinez, and K Olson, and C Hilston
Plasma met-enkephalin and leu-enkephalin in chronic renal failure.
January 1987, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association,
J L Martinez, and K Olson, and C Hilston
On the origin of Leu-enkephalin and Met-enkephalin in the rat neurohypophysis.
October 1985, Endocrinology,
J L Martinez, and K Olson, and C Hilston
Immunohistochemical localization of Met-enkephalin, Met-enkephalin-Arg6-Gly7-Leu8, Met-enkephalin-Arg6-Phe7 and Leu-enkephalin in human adrenal medulla and pheochromocytomas.
January 1984, Peptides,
J L Martinez, and K Olson, and C Hilston
Met- and Leu-enkephalin immunoreactivity in separate neurones.
November 1979, Nature,
Copied contents to your clipboard!