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Using a model of regenerating rat liver, it was shown that the activities of RNA polymerases I and II, and the ratio of free to template engaged form of the enzyme are correlated with the changes in the contents of sphingomyelin in chromatin isolated from cell nuclei of hepatectomized animals. Injections of sphingomyelin to intact and hepatectomized animals in doses increasing its contents in chromatin, stimulate the activity of RNA polymerases I and II and increase the ratio of free to engaged form of the enzyme. Addition of sphingomyelin as a micellar suspension to heterochromatin in vitro facilitates RNA polymerase binding to the template. Removal of sphingomyelin from the intranuclear structures by its degradation with sphingomyelinase results in a loss of activities of both RNA polymerases. It is assumed that sphingomyelin plays a role in the transcriptional activity by changing the structure of the template and that of the enzymes.
A V Alesenko, and
E B Burlakova, and
E A Pantaz
January 1982,
Acta biochimica Polonica,
A V Alesenko, and
E B Burlakova, and
E A Pantaz
May 1993,
Carcinogenesis,
A V Alesenko, and
E B Burlakova, and
E A Pantaz
May 1991,
Biokhimiia (Moscow, Russia),
A V Alesenko, and
E B Burlakova, and
E A Pantaz
December 1970,
European journal of cancer,
A V Alesenko, and
E B Burlakova, and
E A Pantaz
July 1978,
Experimental cell research,
A V Alesenko, and
E B Burlakova, and
E A Pantaz
April 1981,
Biulleten' eksperimental'noi biologii i meditsiny,
A V Alesenko, and
E B Burlakova, and
E A Pantaz
May 1970,
Biochimica et biophysica acta,
A V Alesenko, and
E B Burlakova, and
E A Pantaz
August 1957,
Clinica chimica acta; international journal of clinical chemistry,
A V Alesenko, and
E B Burlakova, and
E A Pantaz
December 1967,
Japanese journal of pharmacology,
A V Alesenko, and
E B Burlakova, and
E A Pantaz
June 1972,
Nature,
