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Using a two-site immunoradiometric assay for rabbit liver ferritin normal NZW rabbits were found to have very low plasma ferritin concentrations (less than 4 micrograms/l). Purified preparations of rabbit liver and kidney ferritin were labelled with 125I and injected into rabbits. Clearance from plasma was extremely rapid with an initial half-life of 1-2 min as measured by immunoprecipitation of labelled ferritin. The rate of clearance was unaffected by the labelling procedure and by the method of ferritin purification. Autoradiography and organ uptake studies showed that 125I-rabbit liver ferritin was removed mainly by liver reticuloendothelial cells, although on a weight basis, spleen had the greatest radioactivity. These studies indicate that rabbit ferritin released into the circulation is promptly cleared by the RES.
A M Covell, and
M Worwood
December 1978,
Calcified tissue research,
A M Covell, and
M Worwood
September 1974,
The Journal of cell biology,
A M Covell, and
M Worwood
June 1974,
Blood,
A M Covell, and
M Worwood
January 1987,
The International journal of biochemistry,
A M Covell, and
M Worwood
June 1959,
The Journal of nutrition,
A M Covell, and
M Worwood
November 1996,
Journal of gastroenterology and hepatology,
A M Covell, and
M Worwood
January 1978,
Verhandlungen der Anatomischen Gesellschaft,
A M Covell, and
M Worwood
March 1975,
Pediatric research,
A M Covell, and
M Worwood
April 1994,
Veterinary immunology and immunopathology,
A M Covell, and
M Worwood
May 1981,
The Journal of clinical investigation,
